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Glycerin: Drug information

Glycerin: Drug information
(For additional information see "Glycerin: Patient drug information" and see "Glycerin: Pediatric drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Avedana Glycerin (Adult) [OTC];
  • Fleet Liquid Glycerin Supp [OTC] [DSC];
  • Pedia-Lax [OTC]
Pharmacologic Category
  • Laxative, Osmotic
Dosing: Adult
Constipation

Constipation: Rectal: One adult suppository once daily as needed or as directed.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Pediatric

(For additional information see "Glycerin: Pediatric drug information")

Note: The suppository dosage form is available in 2 strengths: Pediatric (for use in <6 years of age) and adult (for use in ≥6 years of age); use caution with product selection.

Constipation, occasional or fecal impaction

Constipation, occasional or fecal impaction:

Infants and Children <2 years: Limited data available: Pediatric suppository: Rectal: 1 pediatric suppository once; may repeat daily for up to 3 days if needed (Blackmer 2010; Bolia 2020).

Children 2 to <6 years: Pediatric suppository: Rectal: 1 pediatric suppository once daily as needed.

Children ≥6 years and Adolescents: Adult suppository: Rectal: 1 adult suppository once daily as needed.

Dosing: Older Adult

Refer to adult dosing.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Enema, Rectal:

Fleet Liquid Glycerin Supp: 5.4 g/dose (7.5 mL [DSC])

Suppository, Rectal:

Avedana Glycerin (Adult): 2 g (25 ea, 100 ea)

Pedia-Lax: 1 g (12 ea [DSC]); 2.8 g (4 mL) [contains edetate (edta) disodium]

Generic: 1 g (12 ea, 25 ea); 2 g (12 ea, 24 ea [DSC], 25 ea, 50 ea, 100 ea)

Generic Equivalent Available: US

May be product dependent

Dosage Forms Considerations

Each Pedia-Lax liquid suppository applicator contains 4 mL but delivers 2.7 mL (2.8 g) per dose.

Administration: Adult

Liquid suppository/enema: Remove protective shield; insert tip into rectum with slight side to side movement; squeeze the bulb until nearly all liquid expelled. Gently remove the unit; a small amount of liquid will remain in unit after use.

Solid suppository: Insert suppository high in the rectum and retain ~15 minutes; suppository does not need to melt to produce response.

Administration: Pediatric

Rectal:

Solid suppository: Insert suppository in the rectum and retain 15 minutes; suppository does not need to melt to produce response. If suppository needs to be cut to obtain appropriate dose, cut suppository lengthwise with a sharp knife/blade prior to administration (Bowden 2010).

Liquid suppository/Enema: Administer with patient lying on left side and knees bent or with patient kneeling and head and chest leaning forward until left side of face is resting comfortably. Remove protective shield; gently insert tip into rectum with light side to side movement with tip pointing toward navel; have patient bear down if possible. Squeeze the bottle until nearly all liquid is expelled; a small amount of liquid will remain in unit after use. Gently remove the unit.

Use: Labeled Indications

Constipation: Relief of occasional constipation.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.

Gastrointestinal: Abdominal cramps, rectal irritation, tenesmus

Warnings/Precautions

Other warnings/precautions:

• Appropriate use: For rectal use only. Discontinue use and consult a health care provider if rectal bleeding occurs or if no bowel movement is produced after use; may indicate serious condition.

• Self-medication (OTC use): Consult a health care provider prior to use if stomach pain, nausea, vomiting, or a sudden change in bowel movements lasting >2 weeks occurs, or if you have already used a laxative >1 week. Use may cause stomach discomfort, faintness, rectal burning, and mild cramps. Discontinue use and consult a health care provider if use >1 week is needed.

Warnings: Additional Pediatric Considerations

Frequent use of laxatives may lead to bowel dependence and should be avoided (NASPGHAN/ESPGHAN [Tabbers 2014]).

Use suppository with caution in patients with abdominal pain, nausea, or vomiting; physician should be consulted prior to use. In children, if bowel movement does not occur within 1 hour of use or rectal bleeding occurs, consult a physician.

Metabolism/Transport Effects

None known.

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.

Dichlorphenamide: Laxatives may enhance the hypokalemic effect of Dichlorphenamide. Risk C: Monitor therapy

Pregnancy Considerations

Glycerin suppositories are generally considered acceptable for use during pregnancy (Cullen 2007; Wald 2003).

Mechanism of Action

Osmotic dehydrating agent which increases osmotic pressure; draws fluid into colon and thus stimulates evacuation

Pharmacokinetics

Onset of action: Constipation: Suppository: 15 to 30 minutes.

Absorption: Poorly absorbed.

Pricing: US

Suppository (Avedana Glycerin (Adult) Rectal)

2 g (per each): $0.12

Suppository (Pedia-Lax Rectal)

2.8 g (per mL): $0.22

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Brand Names: International
  • Adulax (ES, UA);
  • Babylax (AT, DE, IL);
  • Bebegel (FR, PT);
  • Benlax (IT);
  • Bulboid (CH);
  • Computer Eye Drops (HK, PH);
  • Covonia (ZW);
  • Covonia Dry & Tickly Cough Linctus (MT);
  • Cristal (CH, FR);
  • Czopki Glicerolowe (PL);
  • Czopki Glicerynowe (PL);
  • Dexeril (RU);
  • Endura (BR);
  • Estrin (MX);
  • Farmino (AR);
  • Finalina (PY);
  • Fleet Baby Lax (PY);
  • Fleet Babylax (CL, SG, VE);
  • Formula Liquida Limpieza (AR);
  • Gely (ES);
  • Glicel (BR);
  • Glicerina (ES, IT);
  • Glicerina Cinfa (ES);
  • Glicerina Quimpe (ES);
  • Glicero Microlismi (GR);
  • Glicerol Vilardell (ES);
  • Glicerolo (IT);
  • Glicerolo Dynacren (IT);
  • Glicerolo Sofar (IT);
  • Glicerotens (ES);
  • Glicev (AR);
  • Glycelax (PT, RU);
  • Glycerol (EG);
  • Glycerol ”Oba” (DK);
  • Glycerotone (BE, FR, LU);
  • Glycilax (AE, BH, CY, DE, KW);
  • Glysup (BD);
  • Gota PC (AR);
  • Hidrate (IN);
  • Jabon de glicerina (ES);
  • Kalmo (EC);
  • Kanova (ES);
  • Kimos (ES);
  • LASS (CR, DO, GT, HN, NI, PA, SV);
  • Laxanova (PE);
  • Laxolyne (AE, BH, ET, QA, SA);
  • Laxovit (BE);
  • Luxoral (IT);
  • Micronema (AR);
  • Milax (DE);
  • Miniderm (FI, SE);
  • Nene-Lax (DE);
  • Neutrobar (MX);
  • Novas (PH);
  • Obifax (ES);
  • PC Grin (MX);
  • Petit Drill (FR);
  • Practomil (CH);
  • Prolax (HR);
  • Q.V. Wash Soap Free Cleansing Liquid (AU);
  • QV Flare (SG);
  • QV Flare Up Cream (AU);
  • Refenax Lagrimas (AR);
  • RubieLax (DE);
  • Slabinorm (UA);
  • Supo Gliz (ES);
  • Supo Kristal (ES);
  • Supos Glicerina Mandri (ES);
  • Suppositoria Glycerini (PL);
  • Tixylix Baby Syrup (MT);
  • Tixylix Toddler Syrup (MT);
  • Verolax (ES, IT, PT);
  • Vitrosups (ES);
  • Vixorfit (AR);
  • Xin Long (CN);
  • Zen Care (MY);
  • Zetalax (IT)


For country code abbreviations (show table)
  1. Avedana (glycerin suppository) [prescribing information]. Pittsburgh, PA: Unipack Inc; November 2021.
  2. Blackmer AB, Farrington EA. Constipation in the pediatric patient: an overview and pharmacologic considerations. J Pediatr Health Care. 2010;24(6):385-99. doi:10.1016/j.pedhc.2010.09.003 [PubMed 20971414]
  3. Bolia R, Safe M, Southwell BR, King SK, Oliver MR. Paediatric constipation for general paediatricians: review using a case-based and evidence-based approach. J Paediatr Child Health. 2020;56(11):1708-1718. doi:10.1111/jpc.14720 [PubMed 33197982]
  4. Bowden VR, Greenberg CS. Pharmacologic management chap 9. Children and Their Families: The Continuum of Care. 2010;11:303-323.
  5. Butler-O'Hara M, Reininger A, Wang H, Amin SB, Rodgers NJ, D'Angio CT. A randomized controlled trial of glycerin suppositories during phototherapy in premature neonates. J Obstet Gynecol Neonatal Nurs. 2017;46(2):220-228. doi:10.1016/j.jogn.2016.10.008 [PubMed 28082211]
  6. Cullen G and O'Donoghue D, "Constipation and Pregnancy," Best Pract Res Clin Gastroenterol, 2007, 21(5):807-18. [PubMed 17889809]
  7. Fleet (glycerin suppository) [prescribing information]. Lynchburg, VA: C.B. Fleet Company; March 2021.
  8. Glycerin suppository [prescribing information]. Woonsocket, RI: CVS Pharmacy Inc; December 2021.
  9. Haiden N, Jilma B, Gerhold B, et al. Small volume enemas do not accelerate meconium evacuation in very low birth weight infants. J Pediatr Gastroenterol Nutr. 2007;44(2):270-273. [PubMed 17255844]
  10. Livingston MH, Elliott T, Williams C, Jones SA, Rosenbaum PL, Walton JM. Glycerin suppositories used prophylactically in premature infants (supp): A pilot randomized controlled trial. J Neonatal Perinatal Med. 2020;13(4):495-505. doi:10.3233/NPM-190310 [PubMed 32083593]
  11. Patel S, Dereddy N, Talati AJ, Gaston K, Dhanireddy R. Glycerin suppositories use in very low birth weight infants. Am J Perinatol. 2017;34(2):169-173. doi:10.1055/s-0036-1584927 [PubMed 27367284]
  12. PediaLax (glycerin suppository) [prescribing information]. Lynchburg, Virginia: C.B. Fleet Company; no date.
  13. Shah V, Chirinian N, Lee S; EPIQ Evidence Review Group. Does the use of glycerin laxatives decrease feeding intolerance in preterm infants?. Paediatr Child Health. 2011;16(9):e68-e70. [PubMed 23115504]
  14. Tabbers MM, DiLorenzo C, Berger MY, et al. Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN. J Pediatr Gastroenterol Nutr. 2014;58(2):258-274. [PubMed 24345831]
  15. Wald A, "Constipation, Diarrhea, and Symptomatic Hemorrhoids During Pregnancy," Gastroenterol Clin North Am, 2003, 32(1):309-22. [PubMed 12635420]
  16. Zenk KE, Koeppel RM, and Liem LA. Comparative efficacy of glycerin enemas and suppository chips in neonates. Clin Pharm. 1993;12(11):846-848. [PubMed 8275649]
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