Diseases associated with a positive ANA

	% with positive ANA
Systemic autoimmune diseases
Mixed connective tissue disease	100%
SLE:
Active	98 to 100%
Remission	90%
Scleroderma	95%
Drug-induced LE	80 to 95%
Sjögren's disease	60%
Rheumatoid arthritis	45%
Raynaud phenomenon	40%
Polymyositis/dermatomyositis	35%
Juvenile idiopathic arthritis	15 to 40%
Organ-specific autoimmune diseases
Autoimmune hepatitis	70%
Primary biliary cholangitis	50 to 70%
Hashimoto's thyroiditis	50%
Graves' disease	50%
Viral infections^*
EBV
HIV
HCV
Parvovirus 19
Malignancies^*
Lymphoproliferative diseases
Paraneoplastic syndromes
Miscellaneous diseases^*
Inflammatory bowel disease
Interstitial pulmonary fibrosis

ANA: antinuclear antibodies; EBV: Epstein-Barr virus; HCV: hepatitis C virus; HIV: human immunodeficiency virus; SLE: systemic lupus erythematosus.

* Although positive tests of ANA are reported in these diseases more often than in healthy controls, precise estimates vary.

Courtesy of Donald B Bloch, MD.

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