Version May 2024
Cough: Topical: Apply to chest and throat up to 3 times daily.
Pain: Topical: Apply to affected areas up to 3 to 4 times daily.
Pruritus: Topical: Apply to affected areas up to 3 to 4 times daily.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
(For additional information see "Camphor and menthol: Pediatric drug information")
Note: Not for oral ingestion; severe, potentially fatal adverse reactions have been reported with ingestion (Ref). Approved ages and uses for products may vary; consult labeling for specific information.
Cough, mild, intermittent: Children ≥2 years and Adolescents: Topical rub (eg, Mentholatum Vaporizing Rub, Vicks VapoRub): Topical (inhalation of vapors): Apply thick layer to throat and chest up to 3 times daily as needed.
Pain (muscle and joint), minor:
Topical cream (eg, Icy Hot, Tiger Balm): Children ≥12 years and Adolescents: Topical: Apply to affected area(s) 3 to 4 times daily as needed; allow at least 2 to 3 hours between applications.
Topical gel (eg, Arctic Relief): Children ≥2 years and Adolescents: Topical: Apply to affected area(s) up to 4 times daily as needed.
Topical ointment (eg, Mentholatum, Vicks VapoRub): Children ≥2 years and Adolescents: Topical: Apply to affected area(s) 3 to 4 times daily as needed.
Pain/pruritus, minor: Children ≥2 years and Adolescents: Topical lotion (eg, Sarna): Topical: Apply to affected area 3 to 4 times daily as needed.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
1% to 10%: Dermatologic: Burning sensation of skin (especially on broken skin)
Concerns related to adverse effects:
• Burns: May cause serious burns (eg, first- to third-degree chemical burns) at the application site. In some cases, hospitalization has been required. Discontinue use and seek medical attention if signs of skin injury (eg, pain, swelling, or blistering) occur following application (FDA Drug Safety Communication 2012).
Special populations:
• Pediatric: The American Academy of Pediatrics suggests that camphor be avoided in pediatric patients because of its lack of efficacy and the well-documented toxicity that may occur with use (AAP 1994). Although toxicity most often results from oral ingestion of topical or inhalation products, combined dermal and inhalation exposure has resulted in toxicity (Love 2004).
Other warnings/precautions:
• Self-medication (OTC use): When using for persistent or chronic cough (as with smoking, asthma, emphysema) or if cough is accompanied by excessive phlegm, consult a health care provider prior to use. Discontinue use and contact a health care provider if condition worsens; if cough symptoms persist for >7 days, come back, or occur with fever, rash, or persistent headache; if pain/pruritus symptoms persist for >7 days or resolve and then recur within a few days; or if irritation or allergic reaction (rash, reddening, burning, blistering, swelling) occurs.
Camphor may cause significant and potentially life-threatening adverse effects in children; most reported cases are with accidental oral ingestions; however, toxicity has also been reported with topical application in an infant. Mild toxicity may cause gastrointestinal effects (eg, nausea, vomiting) or burning sensation; however, severe effects such as restlessness, delirium, seizures, and fatal respiratory depression possibly leading to death can occur with doses as low as 500 mg. Onset of toxicity can occur as rapidly as 5 to 15 minutes after ingestion. Adults appear to be able to tolerate higher ingestions; however, oral ingestion is not recommended (AAP 1994; Khine 2009; Love 2004; Manoguerra 2006; Mathen 2018). Due to the increased potential for toxicity, the limited beneficial effects of camphor, and the availability of safer alternative agents for all approved camphor uses, experts recommend camphor should be used with extreme caution, if at all, in pediatric patients (AAP 1994; Love 2004; PPA [Meyers 2020]).
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Cream, topical:
Icy Hot Advanced Relief: Camphor 11% and menthol 16% (56 g)
Tiger Balm Neck & Shoulder Rub: Camphor 11% and menthol 10% (50 g)
Gel, topical:
Arctic Relief Pain Relieving: Camphor 0.2% and menthol 3.5% (113.4 g)
Camphotrex: Camphor 4% and menthol 10% (85 g)
Camphotrol: Camphor 4% and menthol 10% (85 g)
Ortho-Nesic: Camphor 0.2% and menthol 3.5% (180 mL)
Polar Freeze: Camphor 0.8% and menthol 3.5% (120 g)
Sombra Warm Therapy: Camphor 3% and menthol 3% (85 g, 113 g, 227 g) [alcohol free]
Lotion, topical:
Icy Hot Arthritis Pain Relief: Camphor 4% and menthol 16% (155 g)
Men-Phor: Camphor 0.5% and menthol 0.5% (59 mL [DSC], 222 mL [DSC])
Sarna: Camphor 0.5% and menthol 0.5% (222 mL)
Ointment, topical:
Mentholatum: Camphor 9% and menthol 1.3% (28 g, 85 g)
Soltice Quick-Rub: Camphor 5.1% and menthol 5.1% (40 g, 90 g)
Tiger Balm Extra Strength: Camphor 11% and menthol 10% (18 g)
Tiger Balm Red Extra Strength: Camphor 11% and menthol 10% (4 g)
Tiger Balm Regular Strength: Camphor 11% and menthol 8% (18 g)
Tiger Balm Ultra Strength: Camphor 11% and menthol 11% (8 g, 18 g, 50 g)
Vicks VapoRub Children's: Camphor 4.8% and menthol 2.6%, with eucalyptus oil 1.2% (50 g)
Vicks VapoRub: Camphor 4.7% and menthol 2.6% with eucalyptus oil 1.2% (50 g, 100 g, 170 g)
Patch, transdermal:
DuraProxin: Camphor 3% and menthol 1.25% (30s [DSC])
No
Gel (Camphotrex External)
10-4% (per gram): $13.24
Gel (Camphotrol External)
10-4% (per gram): $13.24
Gel (Ortho-Nesic External)
0.2-3.5% (per mL): $0.99
Gel (Polar Freeze External)
3.5-0.8% (per gram): $0.08
Gel (Rhuli Gel External)
0.3-0.3% (per gram): $0.06
Gel (Sombra Warm Therapy External)
3-3% (per gram): $0.07
Lotion (Sarna External)
0.5-0.5% (per mL): $0.04
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Topical: For topical use only; avoid eyes and mucous membranes. When using for cough, apply a thick layer to chest and throat and cover with a warm, dry cloth if desired; leave clothing loose around the chest and throat to allow vapors to reach mouth and nose. When using for pain or pruritus, apply a thin layer to affected area; may massage into affected areas until fully absorbed. Do not apply on broken, reddened, damaged, swollen skin or on wounds. Do not bandage tightly; some products recommend no bandaging (refer to product labeling). Some products should not be applied to large areas of the body; refer to product labeling. Wash hands with soap and water immediately after applying (unless hands are part of the treatment area). Do not use with heating pad or other heating device. Do not heat, microwave, or add product to hot water or any container where heating water. Do not use with other ointments, creams, sprays, or liniments. Some products recommend not applying 1 hour prior to or 30 minutes after bathing.
Note: Not for oral ingestion; severe, potentially fatal adverse reactions have been reported with ingestion (Ref).
Topical: For external use only; avoid eyes and mucous membranes. Apply to clean, dry skin; do not apply on broken, reddened, damaged, swollen skin, or on wounds; do not bandage tightly or use a heating pad. Do not heat, microwave, or add to hot water or containers which heat water. Wash hands with soap and water immediately after applying (unless hands are part of the treatment area).
Cream, Ointment: Do not apply 1 hour prior to or 30 minutes after bathing.
Rub: Apply a thick layer to throat and chest; may cover with warm, dry cloth if desired; leave clothing loose around chest and throat to allow vapors to reach nose and mouth.
Note: Specific indications may vary based on product; also refer to manufacturer's labeling.
Cough: Temporary relief of cough due to minor throat and bronchial irritation associated with the common cold; reduces cough to aid in sleep.
Pain: Temporary relief of minor aches and pains of muscles and joints (eg, arthritis, bruises, cramps, neuralgia, simple backache, sprains, strains).
Pruritus: Temporary relief of pain and itching associated with minor skin irritations (eg, insect bites, minor burns/cuts/scrapes, poison ivy/oak/sumac, sunburn).
KIDs List: Camphor, when used in pediatric patients <18 years of age, is identified on the Key Potentially Inappropriate Drugs in Pediatrics (KIDs) list and should be used with caution due to risk of seizures (weak recommendation; low quality of evidence) (PPA [Meyers 2020]).
None known.
There are no known significant interactions.
Refer to individual monographs.
Refer to individual monographs.
Camphor: Rubefacient and mild analgesic.
Menthol: Dilates the blood vessels, causing a sensation of coldness followed by an analgesic effect; relieves itching.
Refer to individual agents.
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