Version May 2024
Cold sore/fever blister: Topical: Apply 5 times daily to affected area of face or lips. Start at first sign of cold sore or fever blister and continue until healed. If not healed within 10 days, discontinue use and contact health care provider.
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
Refer to adult dosing.
Cold sore/fever blister: Children ≥12 years and Adolescents: Refer to adult dosing.
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no adverse reactions listed in the manufacturer's labeling.
OTC labeling: When used for self-medication, do not use if you have hypersensitivity to docosanol or any component of the formulation
Concerns related to adverse effects:
• Hypersensitivity: Severe allergic reactions (eg, hives, facial swelling, wheezing/difficulty breathing, rash, shock) may occur with use; discontinue and seek medical attention immediately if an allergic reaction occurs.
Dosage form specific issues:
• Benzyl alcohol and derivatives: Some dosage forms may contain benzyl alcohol; large amounts of benzyl alcohol (≥99 mg/kg/day) have been associated with a potentially fatal toxicity (“gasping syndrome”) in neonates; the “gasping syndrome” consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension and cardiovascular collapse (AAP ["Inactive" 1997]; CDC, 1982); some data suggests that benzoate displaces bilirubin from protein binding sites (Ahlfors, 2001); avoid or use dosage forms containing benzyl alcohol with caution in neonates. See manufacturer’s labeling.
Other warnings/precautions:
• Appropriate use: For external use only; do not apply to inside of mouth or around eyes. Apply at the first sign of cold sore/fever blister (tingle); early treatment ensures best results. Do not share product with others. Discontinue use and contact a health care provider if the condition gets worse or is not healed within 10 days.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Cream, External:
Abreva: 10% (2 g) [contains benzyl alcohol, propylene glycol]
FT Docosanol: 10% (2 g) [contains benzyl alcohol, propylene glycol]
Generic: 10% (2 g)
Yes
Cream (Abreva External)
10% (per gram): $9.28
Cream (Docosanol External)
10% (per gram): $8.02 - $10.80
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
For topical use on the face or lips; avoid applying directly inside the mouth or around the eyes. Wash hands before and after use. Apply to affected area only; rub in gently and completely.
Topical: For topical use on the face or lips; avoid applying directly inside the mouth or around the eyes. Wash hands before and after use. Apply at the first sign/symptom of cold sore or fever blister (eg, tingle, redness, bump, itch). Remove cosmetics (eg, lipstick) and clean area prior to application. Apply to affected area only; rub in gently and completely. May apply lipstick over docosanol using a separate applicator (eg, cotton swab) to avoid spreading the infection.
Cold sore/fever blister: Treatment of cold sores/fever blisters on the face or lips.
None known.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.
Talimogene Laherparepvec: Antiherpetic Antivirals may diminish the therapeutic effect of Talimogene Laherparepvec. Risk C: Monitor therapy
Prevents viral entry and replication at the cellular level
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