Version June 2024
| Mimickers of mycosis fungoides | Features suggestive of reactive inflammatory process |
| Drug-induced pseudolymphoma | Primarily clinical |
| Lichen sclerosis | Location (genital), dense homogenized papillary dermal collagen |
| Lichen striatus | Spongiosis, perieccrine inflammation |
| Lichenoid/lymphomatoid keratosis | Wedge-shaped hypergranulosis, dyskeratotic keratinocytes, eosinophils, adjacent epithelial neoplasm (seborrheic keratosis, solar lentigo, etc) |
| Lymphomatoid contact dermatitis | Spongiosis, papillary dermal edema, flask-shaped intraepidermal abscesses |
| Actinic reticuloid/chronic actinic dermatitis | Spongiosis, epidermal acanthosis, CD8+ lymphocytes predominate |
| Vitiligo (inflammatory stage) | Primarily clinical |
| Pigmented purpuric dermatitis | Lack of cytologic atypia, lack of papillary dermal fibrosis |
| Fungal infection | Neutrophils in stratum corneum, positive Periodic Acid-Schiff (PAS) stain |
| Arthropod assault | Spongiosis, eosinophils, lymphoid follicles |
| Secondary syphilis | Plasma cells, endarteritis, basal vacuolar interface changes |
| Mimickers of CD30+ lymphoproliferative disorders | Features suggestive of reactive inflammatory process |
| Viral infections (Orf, Milker's nodule, molluscum contagiosum, herpes simplex) | Scattered CD30+ cells, viropathic changes |
| Arthropod assault | Scattered CD30+ cells, eosinophils, spongiosis |
| Mimickers of primary cutaneous B-cell lymphoma | Features suggestive of reactive inflammatory process |
| Lymphomatoid drug reaction | Primarily clinical |
| Persistent nodular arthropod bite reaction | Epidermal spongiosis, eosinophils, endothelial swelling |
| Lymphocytoma cutis | Well-formed germinal centers, "top-heavy" infiltrate, tingible body macrophages |
| Tattoo reaction | Tattoo pigment |
| Vaccine reaction | Central vertical focus of degeneration and fibrosis |
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