Glomerular thrombotic microangiopathy in hemolytic uremic syndrome

Histopathology of a patient with hemolytic uremic syndrome. Panel A demonstrates fibrin deposition in the glomerular capillaries (arrow). Panel B shows narrowing of the glomerular arteriole due to widening of the subendothelial space (arrow). Panel C demonstrates double contour appearance of glomerular capillary wall and widening of the subendothelial space (arrow). Panel D is an electron micrograph showing swollen endothelial cells.