Topical ophthalmologic medications for corneal abrasion

Medication	Brand name(s)	Dose
Topical antibiotics*
Erythromycin 0.5% ophthalmic ointment	Ilotycin, Romycin, Diomycin	0.5 inch (1.25 cm) ribbon, four times per day for three to five days
Trimethoprim-polymyxin B 0.1%-10,000 units/mL ophthalmic solution	Polytrim, PMS-Polytrimethoprim	1 drop, four times per day for three to five days
Sulfacetamide 10% ophthalmic ointment^¶	Generic only	0.5 inch (1.25 cm) ribbon, four times per day for three to five days
Sulfacetamide 10% ophthalmic solution^¶	Bleph-10, Diasulf, Sulamyd	1 to 2 drops, four times per day for three to five days
Antipseudomonal topical antibiotics* (preferred in contact lens wearers)
Ciprofloxacin 0.3% ophthalmic ointment	Ciloxan, Ciprodar ointment	0.5 inch (1.25 cm) ribbon, four times per day for three to five days
Ciprofloxacin 0.3% ophthalmic solution	Ciloxan, Ciprodar solution	1 to 2 drops, four times per day for three to five days
Ofloxacin 0.3% ophthalmic solution	Ocufloxm Exocin	1 to 2 drops, four times per day for three to five days
Tobramycin 0.3% ophthalmic ointment	Tobrex, Tobral	0.5 inch (1.25 cm) ribbon, two to three times per day for three to five days
Tobramycin 0.3% ophthalmic solution	Tobrex, Tobral	1 to 2 drops, four times per day for three to five days
Gentamicin 0.3% ophthalmic ointment^Δ	Gentak, Garamycin ointment	0.5 inch (1.25 cm) ribbon, two to three times per day for three to five days
Gentamicin 0.3% ophthalmic solution^Δ	Garamycin, Gentocin	1 to 2 drops, four times per day for three to five days
Topical NSAIDs
Bromfenac 0.07 or 0.09% once-daily ophthalmic solution	Bromday, Prolensa	1 drop, once per day for two to three days
Diclofenac 0.1% ophthalmic solution	Voltaren Ophtha	1 drop, four times per day for two to three days
Ketorolac 0.4 or 0.5% ophthalmic solution	Acular LS (0.4%), Acular (0.5%)	1 drop, four times per day for two to three days
Ketorolac 0.45% ophthalmic solution (preservative free)	Acuvail	1 drop, four times per day for two to three days
Topical cycloplegics (for office use only in patients with ciliary spasm)
Cyclopentolate 1% ophthalmic solution	Cyclogyl, AK Pentolate	1 drop, may repeat in five minutes if needed
Homatropine 2 or 5% ophthalmic solution	Isopto Homatropine, Homatropaire	1 drop, may repeat in five minutes if needed

Brand (trade) names listed above are for preparations available in United States, Canada, and some other countries. Some brand versions may not be available.
* Topical antibiotics are prescribed to prevent bacterial superinfection. Ointments rather than drops may be preferred due to their lubricant and protective functions. Topical antibiotic dosing frequency provided above reflects mild to moderate infection; more frequent administration as advised by an ophthalmologist is indicated for more severe infections. Dosing frequency may be decreased to twice per day if there is no foreign body sensation, and may be discontinued when the patient is asymptomatic for 24 hours. Topical preparations containing steroids should not be used (refer to accompanying text).
¶ Rarely, sulfacetamide is associated with serious allergic reactions, including Stevens-Johnson syndrome.
Δ Aminoglycosides can be toxic to the corneal epithelium and should be avoided, except as an alternative in abrasions associated with recent contact lens wear and if a topical fluoroquinolone is not available or cannot be used.

Adapted with permission from Evaluation and Management of Corneal Abrasions, January 15, 2013, Vol 87, No 2, American Family Physician. Copyright © 2013 American Academy of Family Physicians. All Rights Reserved.

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Topical ophthalmologic medications for corneal abrasion