(For additional information
see "Fusidic acid (United States: Not available) (topical): Patient drug information")
For abbreviations, symbols, and age group definitions used in Lexicomp (
show table)
Pharmacologic Category
-
Antibiotic, Miscellaneous;
-
Antibiotic, Topical
Dosing: Adult
Skin infections
Skin infections:
Topical: Apply small amount to affected area 2 to 3 times daily for 7 to 14 days. If a gauze dressing is used, frequency of application may be reduced to once or twice daily.
Dosing: Older Adult
Refer to adult dosing.
Dosing: Pediatric
Skin infections
Skin infections: Children and Adolescents: Topical: Refer to adult dosing.
Adverse Reactions
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
Frequency not defined: Central nervous system: Pain (with treatment of deep leg ulcers)
Postmarketing and/or case reports: Anaphylaxis (Park 2013), angioedema, application site irritation, application site pain, conjunctivitis, dermatitis, erythema, hypersensitivity reaction, pruritus, skin blister, skin irritation, skin rash, urticaria
Contraindications
Hypersensitivity to fusidic acid or any component of the formulation
Warnings/Precautions
Concerns related to adverse effects:
• Skin reactions: Excipients in the topical cream and ointment may cause local skin reaction (eg, contact dermatitis); discontinue use if irritation or sensitization develops.
• Superinfection: Prolonged use may result in superinfection (including fungal infections). Discontinue use if superinfection occurs; evaluate and treat appropriately.
Other warnings/precautions:
• Appropriate use: Do not use topical cream or ointment near the eye; conjunctival irritation may occur. Supplemental systemic therapy may be necessary for severe or refractory lesions.
Product Availability
Not available in the US
Generic Equivalent Available: US
Yes
Dosage Forms: Canada
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Cream, External:
Fucidin: 2% (5 g, 30 g)
Ointment, External:
Fucidin: 2% (5 g, 30 g)
Administration: Adult
For topical use only; do not use near the eyes. Crust of impetigo contagiosa does not need to be removed prior to application of cream or ointment. When indicated, incision and drainage of infected lesions should precede application of the cream or ointment.
Administration: Pediatric
Topical: For topical use only; do not use near the eyes. Crust of impetigo contagiosa does not need to be removed prior to application of cream or ointment. When indicated, incision and drainage of infected lesions should precede application of the cream or ointment.
Use: Labeled Indications
Note: Not approved in the United States.
Skin infections: Treatment of primary (eg, impetigo contagiosa, erythrasma) and secondary (eg, infected wounds, infected burns) skin infections caused by susceptible Staphylococcus aureus, Streptococcus spp., Corynebacterium minutissimum.
Metabolism/Transport Effects
None known.
Drug Interactions
There are no known significant interactions.
Pregnancy Considerations
Adverse effects were not observed in animal reproduction studies. Fusidic acid crosses the placenta following systemic administration. Systemic absorption following topical application is minimal.
Breastfeeding Considerations
It is not known if fusidic acid is present in breast milk following topical application.
Fusidic acid is present in breast milk following systemic administration; however, systemic absorption following topical application is minimal. Topical fusidic acid has been evaluated for Staphylococcus aureus impetigo infection in breastfeeding patients with sore, cracked nipples; fusidic acid was not effective for systemic infection that may lead to mastitis (Livingstone 1999).
Mechanism of Action
Inhibits protein synthesis by blocking aminoacyl-tRNA transfer to protein in susceptible bacteria.
Pharmacokinetics (Adult Data Unless Noted)
Absorption: ~2% (Fucidin H Canadian product labeling 2014)
Brand Names: International
International Brand Names by CountryFor country code abbreviations (
show table)
-
(AE) United Arab Emirates: Balad | Dermofucin | Fucidin | Fucithalmic | Fudion | Fusibact | Fusiderm | Fusilox | Fusiver | Futasole | Uciderm | Zeta;
-
(AR) Argentina: Acifusin | Arzimol | Drum | Fucidin | Fusimed | Fusitop | Gelbiotic | Klonafusid;
-
(AT) Austria: Fucidin;
-
(AU) Australia: Fucidin;
-
(BD) Bangladesh: Facid | Fucidin | Fusidate | Fusidin;
-
(BE) Belgium: Affusine | Fucidin | Fucidin impexeco | Fusidine teva;
-
(BF) Burkina Faso: Nadiclox;
-
(BG) Bulgaria: Fucidin;
-
(BR) Brazil: Acido fusidico | Veruf | Verutex;
-
(CH) Switzerland: Fucidin | Fusicutan;
-
(CI) Côte d'Ivoire: Agiderm | Fusigen | Nadiclox;
-
(CL) Chile: Afugerm | Arzimol | Fucidin | Fusimed;
-
(CN) China: Fucidin | Phudicin;
-
(CO) Colombia: Acido fusidico | Afusid | Afusil topic | Derzel | Fucidin | Fucifar | Fucilix | Fudine | Fusiderm | Fusifar | Fusimed | Fusitop | Fusitrex | Infusid | Klinidox | Topisept | Uniderm;
-
(CZ) Czech Republic: Fucidin;
-
(DE) Germany: Fucidin | Fucidine | Fusicutan | Fusidinsaeure Acis | Fusidinsaeure ratiopharm;
-
(DO) Dominican Republic: Acido fusidico | Acido fusidico Inmenol | Eurofusid | Fucidin | Fucimax | Fusibiotic | Fusicream | Fusidex | Fusiphar | Uniderm;
-
(EC) Ecuador: Acido fusidico | Acido fusidico aurochem | Fucidin;
-
(EE) Estonia: Fucidin;
-
(EG) Egypt: Fuci top | Fucidel | Fucidin | Fuciphac | Fucithalmic | Fusi | Fusiderm | Fusidictam | Futasole | Staph buster | Unistafusin;
-
(ES) Spain: Amigermol | Fucidine | Fusidato de sodio isdin;
-
(ET) Ethiopia: Foban | Fusiderm | Sodium fucidate | Sodium fusidate;
-
(FI) Finland: Fucidin | Fusidic acid orifarm;
-
(FR) France: Acide fusidique Arrow | Acide fusidique biogaran | Acide fusidique EG | Acide fusidique mylan | Acide fusidique ratiopharm | Acide fusidique sandoz | Acide fusidique zentiva | Fucidine;
-
(GB) United Kingdom: Fucidin;
-
(GR) Greece: Emfucin | Flusterix | Fucidin | Fusidic acid/promopharma | Fusidic acid/Target | Fusindac;
-
(HK) Hong Kong: Aptusiderm | Axcel Fusidic | Defuzin | Disuf | Eucidate | Fucidin | Fulosin | Fusiderm | Fusidsyn | Fusigen | Fuson | Neo fusic | Phudicin | Qualifutin;
-
(HR) Croatia: Fusicutan;
-
(HU) Hungary: Fucidin;
-
(ID) Indonesia: Acdat | Afucid | Fucidin | Fucilex | Fuladic | Fusigra | Fuson | Fusycom | Futaderm;
-
(IE) Ireland: Fucidin;
-
(IL) Israel: Fucidin | Staphiderm;
-
(IN) India: Aloederm f | Bactafuz | Bactirest | Belbact | Chitomesh sf | Derrim | Fac | Flusid | Fsd | Fsol | Ft mac | Fuben | Fuciderm | Fucidin | Fucidin wallace | Fucin | Fucinex | Fucinova | Fucipex | Fuciskin | Fudic | Fudic b | Fudic Bnf | Fudosis | Fusee | Fusep | Fusiat | Fusiate | Fusibact | Fusibest | Fusicare | Fusid | Fusida | Fusiderm | Fusidox | Fusifix | Fusigen | Fusihalt | Fusim | Fusinia | Fusiol | Fusiol m | Fusipar | Fusirose | Fusivic | Fusiwal | Fuson | Fussi | Fuster | Futop | Fuzinix | Gentopic-fa | Siofin | Sofinox | Stafoban | Sudif;
-
(IQ) Iraq: As fuciden | Fuocidad | Fusicure | Hucidin;
-
(IT) Italy: Acido fusidico teva | Afugerm | Dermomycin | Fucidin;
-
(JO) Jordan: Dermocid | Dermofucin | Fucidin | Fucithalmic | Fudion | Fusibact | Fusiderm | Fusiver | Fusylin | Newsen | Topidic | Uciderm | Zeta;
-
(JP) Japan: Fucidin leo;
-
(KE) Kenya: Axcel fusidic acid | Bactafuz | Fucidin | Fusibact | Fusifen | Fusigen | Fusigo | Futop | Nopetigo | Sudif | Topidic;
-
(KR) Korea, Republic of: Antigel | Austin sodium fusidate | Balad | Bardin | Barin | Barten | Clidin f | Curidin | Dongwha fucidin | Fasildin | Fucidemo | Fuciden | Fucidin | Fucigel | Fucimedine | Fudikin | Fudin | Fumacine | Furacin | Fusden | Fusidana | Fusidate | Fusiden | Fusiderm | Fusimed | Fusina | Fustan | Hubala | Huskin | Innersol | Neociderm | Parason | Samik Sodium Fusidate | Scare;
-
(KW) Kuwait: Balad | Fucidin | Fucithalmic | Fudion | Fusibact | Fusitin | Fusiver | Futasole | Zeta;
-
(LB) Lebanon: Dermicin | Dermofucin | Fucidin | Fucimed | Fucithalmic | Fusiderm | Futasole | Futazole | Tiremix | Topidic | Zeta;
-
(LT) Lithuania: Fucidin | Fucidin natrium | Fusidate de sodium pierre fabre | Fusidic acid sandoz;
-
(LU) Luxembourg: Affusine | Fucidin;
-
(LV) Latvia: Fucidin | Fucidin natrium;
-
(MA) Morocco: Agiderm | Coccidin | Fucidine | Uciderm;
-
(MX) Mexico: Aceler | Amigermol | Fucidin | Sidantil | Uniderm;
-
(MY) Malaysia: Defuzin | Disuf | Duzen | Dyna fusidic | Foban | Fucid | Fucidin | Fuderm | Fusidic | Fusifen | Fusigen | Germacid | Pharmaniaga Fusidic | Sabacid;
-
(NL) Netherlands: Affusine | Fucid | Fucidin | Fucidine | Fusidinezuur;
-
(NO) Norway: Fucidin;
-
(NZ) New Zealand: Dp fusidic acid | Fucidin;
-
(PE) Peru: Acido fusidico | Bactafuz | Direpor | Fucidin | Fusibiotic | Fusimed | Niofen;
-
(PH) Philippines: Bactrofuse | Flexid | Fucid | Fucidin | Fucinex | Fusigen | Fusoderm | Fuson | Hopaq | Sofinox | Woncare;
-
(PK) Pakistan: Amfic | Arsibact | Austafus | Bacidic | Bactafuz | Bio Porena | Busid | Cidic | Curoderm | Dermodic | Dermy | Evocort | Exiderm | Fosedic | Fosic | Fucid | Fucidin | Fucithalmic | Fucitop | Fucort | Fucyn | Fude | Fuderm | Fudic | Furocid | Fusac | Fusi topical | Fusia | Fusibact | Fusiderm | Fusifix | Fusil | Fusimax | Fusimed | Fusimin | Fusinax a | Fusinor | Fusipro | Fusiwel | Fyrisum | Hifuzin | Infacid | Jusidic | Kardic | Melas | Mrozan | No boyle | Noviskin | Pathoderm | Phusilan | Sirulz | Sofinox | Strofus | Ucid | Udic | Usid | Xedin | Zudic;
-
(PL) Poland: Dermafusin | Fucidin | Fusacid | Hylosept;
-
(PT) Portugal: Acido fusidico | Acido fusidico famoz | Fucidine | Fusextrine | Fysubac | Infloc | Nadiclox;
-
(PY) Paraguay: Acido fusidico dasanti | Acifusin | Dankesil | Fucidin | Fusifar | Fusimed | Fusix galeno | Iretien;
-
(QA) Qatar: Balad | Balad (Fusidic Acid) | Dermofucin | Dermofucin (Fusidic Acid) | Fucidin | Fucidin (Fusidic Acid) | Fucidin Intertulle | Fucimed | Fudion | Fusibact | Fusibact (Fusidic Acid) | Fusiderm | Fusiderm (Fusidic Acid) | Fusitin | Fusitin (Fusidic Acid) | Fusiver | Fusix Derma | Futasole | Futasole (Fusidic Acid) | Topidic | Uciderm (Fusidate Sodium) | Uciderm (Fusidic Acid) | Zeta | Zeta (Fusidic Acid);
-
(RO) Romania: Fucidin;
-
(RU) Russian Federation: Fucidin | Fusiderm;
-
(SA) Saudi Arabia: Balad | Dermofucin | Fucidin | Fucithalmic | Fudin | Fudion | Fusibact | Fusiderm | Fusiver | Futasole | Topidic | Uciderm | Zeta;
-
(SE) Sweden: Fucidin | Fucidine | Fucithalmic;
-
(SG) Singapore: Defuzin | Disuf | Foban | Forsuderm | Fudikin | Fustadin;
-
(SI) Slovenia: Fucidin;
-
(SK) Slovakia: Fucidin;
-
(TH) Thailand: Axcel fusidic acid | Difusin | Foban | Fucidin | Fusid | Germidic | Lucinar;
-
(TN) Tunisia: Acid Fusidique Opalia | Afucid | Afusidic | Fucidate | Fucidine | Fumidex | S.fusidate | Tricidine | Uciderm;
-
(TR) Turkey: Fucibest | Fucidin | Fucidox | Fucitec | Fucitec pomad | Fusidas | Fusix Derma | Fusix derma | Helkort | Stafine | Tiremix;
-
(TW) Taiwan: Conlifu | Fucidin | Fucidin c | Fucimycin | Fudin | Fugen | Fulijing | Fulosin | Fusiden | Fusider | Fusidic | Fusidin | Fusidine | Fusik | Fuskin | Fusotex | Futen | Kangfujing | Sofuni;
-
(UA) Ukraine: Fusicutan;
-
(UG) Uganda: Axcel fusidic acid | Fusiderm | Fusigen | Fusigo | Topidic;
-
(UY) Uruguay: Arzimol | Fucidin | Fusifar | Fusimed;
-
(VE) Venezuela, Bolivarian Republic of: Acido fusidico | Fucidin;
-
(VN) Viet Nam: Pusadine;
-
(ZA) South Africa: Fucidin;
-
(ZM) Zambia: Foban;
-
(ZW) Zimbabwe: Axcel fusidic acid | Sofudac
