Survival following allogeneic hematopoietic cell transplantation based on the degree of HLA matching
Survival of patients with early, intermediate, and advanced disease depending on degree of HLA matching (8/8, 7/8, and 6/8) for HLA-A, -B, -C, and -DRB1.
(A) Early-stage disease for 8/8, 7/8, and 6/8, respectively: one-year survival 63, 52, and 39 percent; five-year survival 50, 39, and 28 percent.
(B) Intermediate-stage disease for 8/8, 7/8, and 6/8, respectively: one-year survival 48, 40, and 32 percent; five-year survival 32, 27, and 22 percent.
(C) Advanced-stage disease for 8/8, 7/8, and 6/8, respectively: one-year survival 31, 29, and 24 percent; five-year survival 17, 15, and 10 percent.
Reproduced with permission of the American Society of Hematology, from Lee SJ, Klein J, Haagenson M, et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood 2007; 110:4576; permission conveyed through Copyright Clearance Center, Inc.
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