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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده: 3

Additives and excipients in commonly available insulin products*

Additives and excipients in commonly available insulin products*
Insulin Trade name in the United States Protamine
(yes/no)
Others Availability outside of the United States
Rapid acting (duration 2 to 4 hours)
Aspart NovoLog, Fiasp, Merilog No Metacresol, glycerin, phenol, zinc, niacinamide (Fiasp only) Yes (eg, NovoRapid, Fiasp, Kirsty, Trurapi)
Lispro Humalog, Admelog, Lyumjev No Metacresol, glycerin, phenol (Humalog only), zinc, tromethamine Yes (eg, Humalog, Admelog, Liprolog)
Glulisine Apidra No Metacresol, tromethamine, polysorbate 20 Yes (Apidra)
Short acting (duration 5 to 8 hours)
Regular (U-100) Humulin R, Novolin R No Metacresol, glycerin, zinc Yes (eg, Actrapid, Humulin, Novolin)
Intermediate acting (duration 14 to 24 hours)
NPH (human insulin isophane suspension) Humulin N, Novolin N Yes Metacresol, glycerin, phenol, zinc Yes (eg, Humulin N)
Regular U-500 (concentrated) Humulin R U-500 No Metacresol, glycerin, zinc Yes (eg, Humulin R regular U-500, Entuzity)
Intermediate-acting fixed-ratio mixtures (duration 14 to 24 hours with a more rapid peak)
Lispro protamine (75%) and lispro (25%) or lispro protamine (50%) and lispro (50%) Humalog Mix 75/25 and Humalog Mix 50/50 Yes Metacresol, glycerin, phenol, zinc Yes (eg, Humalog Mix, Humalog Mix 25)
Aspart protamine (70%) and aspart (30%) NovoLog Mix 70/30 Yes Metacresol, glycerin, phenol, zinc Yes (eg, NovoMix, NovoMix 30)
NPH (70%) and regular (30%) Humulin 70/30 and Novolin 70/30 Yes Metacresol, glycerin, phenol, zinc Yes (eg, Humulin 70/30, Novolin ge, Acraphane, Mixtard)
Intermediate to long acting (duration 6 to 24 hours, dose dependent)
DetemirΔ Levemir No Metacresol, glycerin, phenol, zinc Yes (Levemir)
Long acting (duration 20 to >24 hours)
Glargine Lantus, Basaglar, Toujeo, Rezvoglar, Semglee No Metacresol, zinc, glycerin, polysorbate 20 (Lantus and Semglee only) Yes (Lantus, Toujeo, Semglee, Abasaglar)
Degludec Tresiba No Metacresol, glycerin, phenol, zinc acetate Yes (Tresiba)
Ultra long acting (duration 1 week)
Icodec Not available No Metacresol, glycerin, phenol, zinc Yes (Awigli)
Insulin products listed are produced by recombinant DNA technology utilizing Saccharomyces cerevisiae (baker's yeast) or the nonpathogenic strain of Escherichia coli.

DNA: deoxyribonucleic acid; NPH: neutral protamine Hagedorn.

* According to product information in the United States. Inactive ingredients may change. Check local prescribing information.

¶ Glycerin is referred to as glycerol in some countries outside the United States. Metacresol (m-cresol) is a phenol-type preservative. Products are pH adjusted.

Δ Insulin detemir is discontinued in the United States but may remain available elsewhere.

◊ Insulin icodec is not available in the United States but has regulatory approval in some other countries (eg, Canada, Europe, Australia, Japan). Product characteristics listed are based on prescribing information in Canada.

Graphic 91420 Version 12.0

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