August 2025
| Insulin | Trade name in the United States | Protamine (yes/no) | Others¶ | Availability outside of the United States |
| Rapid acting (duration 2 to 4 hours) | ||||
| Aspart | NovoLog, Fiasp, Merilog | No | Metacresol, glycerin, phenol, zinc, niacinamide (Fiasp only) | Yes (eg, NovoRapid, Fiasp, Kirsty, Trurapi) |
| Lispro | Humalog, Admelog, Lyumjev | No | Metacresol, glycerin, phenol (Humalog only), zinc, tromethamine | Yes (eg, Humalog, Admelog, Liprolog) |
| Glulisine | Apidra | No | Metacresol, tromethamine, polysorbate 20 | Yes (Apidra) |
| Short acting (duration 5 to 8 hours) | ||||
| Regular (U-100) | Humulin R, Novolin R | No | Metacresol, glycerin, zinc | Yes (eg, Actrapid, Humulin, Novolin) |
| Intermediate acting (duration 14 to 24 hours) | ||||
| NPH (human insulin isophane suspension) | Humulin N, Novolin N | Yes | Metacresol, glycerin, phenol, zinc | Yes (eg, Humulin N) |
| Regular U-500 (concentrated) | Humulin R U-500 | No | Metacresol, glycerin, zinc | Yes (eg, Humulin R regular U-500, Entuzity) |
| Intermediate-acting fixed-ratio mixtures (duration 14 to 24 hours with a more rapid peak) | ||||
| Lispro protamine (75%) and lispro (25%) or lispro protamine (50%) and lispro (50%) | Humalog Mix 75/25 and Humalog Mix 50/50 | Yes | Metacresol, glycerin, phenol, zinc | Yes (eg, Humalog Mix, Humalog Mix 25) |
| Aspart protamine (70%) and aspart (30%) | NovoLog Mix 70/30 | Yes | Metacresol, glycerin, phenol, zinc | Yes (eg, NovoMix, NovoMix 30) |
| NPH (70%) and regular (30%) | Humulin 70/30 and Novolin 70/30 | Yes | Metacresol, glycerin, phenol, zinc | Yes (eg, Humulin 70/30, Novolin ge, Acraphane, Mixtard) |
| Intermediate to long acting (duration 6 to 24 hours, dose dependent) | ||||
| DetemirΔ | Levemir | No | Metacresol, glycerin, phenol, zinc | Yes (Levemir) |
| Long acting (duration 20 to >24 hours) | ||||
| Glargine | Lantus, Basaglar, Toujeo, Rezvoglar, Semglee | No | Metacresol, zinc, glycerin, polysorbate 20 (Lantus and Semglee only) | Yes (Lantus, Toujeo, Semglee, Abasaglar) |
| Degludec | Tresiba | No | Metacresol, glycerin, phenol, zinc acetate | Yes (Tresiba) |
| Ultra long acting (duration 1 week) | ||||
| Icodec◊ | Not available | No | Metacresol, glycerin, phenol, zinc | Yes (Awigli) |
DNA: deoxyribonucleic acid; NPH: neutral protamine Hagedorn.
* According to product information in the United States. Inactive ingredients may change. Check local prescribing information.
¶ Glycerin is referred to as glycerol in some countries outside the United States. Metacresol (m-cresol) is a phenol-type preservative. Products are pH adjusted.
Δ Insulin detemir is discontinued in the United States but may remain available elsewhere.
◊ Insulin icodec is not available in the United States but has regulatory approval in some other countries (eg, Canada, Europe, Australia, Japan). Product characteristics listed are based on prescribing information in Canada.
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