Chance of side effects with common tricyclic antidepressants ("TCAs")

Generic name	US brand name	Dry mouth, constipation trouble urinating, dizziness	Weight gain	Problems with sex	Drowsiness	Trouble sleeping, jitteriness
Amitriptyline	Elavil	●●●●	●●●●	●●●	●●●●
Amoxapine	Asendin (only sold as generic in the US)	●●	●●	Might happen, but not well studied	●●	●●
Clomipramine	Anafranil	●●●●	●●●●	●●●●	●●●●	●
Desipramine	Norpramin	●	●	Might happen, but not well studied	●●●●	●
Doxepin	Silenor, Sinequan	●●●	●●●●	●●●	●●●
Imipramine	Tofranil	●●●	●●●●	●●●	●●●	●
Nortriptyline	Pamelor	●●	●	Might happen, but not well studied	●●
Protriptyline	Vivactil (only sold as generic in the US)	●●	●	●●●	●	●

This table shows which side effects are seen with different TCAs. Side effects are usually mild and can improve over a few weeks as your body gets used to the medicine. The more dots there are, the higher the risk of a side effect is:

No dots: None

1 dot (●): Slight

2 dots (●●): Low

3 dots (●●●): Moderate

4 dots (●●●●): High

Side effects happen less often with the lower doses used for pain.

Many of these medicines can affect your blood pressure and make you feel lightheaded when you stand up. This could increase your risk of falling. Older people might not be able to take TCAs, because side effects such as memory problems and confusion can be worse.

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Chance of side effects with common tricyclic antidepressants ("TCAs")

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