Duodenal polyp with high-grade dysplasia

(A) Medium power view of one of the duodenal polyps contains straight tubular glands lined by hyperchromatic stratified epithelial cells replacing the normal duodenal mucosa.
(B) High power view of the same duodenal polyp shows evidence of high-grade dysplasia characterized by nuclear enlargement (arrow) and loss of polarity. In low-grade dysplasia, the nuclei are long and thin, while in high-grade dysplasia, the nuclei enlarge, round up, and become displaced towards the surface.