NCI CTCAE v5.0 agitation, confusion, delirium

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Agitation	Mild mood alteration	Moderate mood alteration	Severe agitation; hospitalization not indicated	Life-threatening consequences; urgent intervention indicated
Confusion	Mild disorientation	Moderate disorientation; limiting instrumental ADL*	Severe disorientation; limiting self-care ADL*	Life-threatening consequences; urgent intervention indicated
Delirium	Mild acute confusional state	Moderate and acute confusional state; limiting instrumental ADL*	Severe and acute confusional state; limiting self-care ADL*; urgent intervention indicated; new onset	Life-threatening consequences, threats of harm to self or others; urgent intervention indicated	Death

Agitation is characterized by a state of restlessness associated with unpleasant feelings of irritability and tension. Confusion is characterized by a lack of clear and orderly thought and behavior. Delirium is characterized by the acute and sudden development of confusion, illusions, movement changes, inattentiveness, agitation, and hallucinations; it is usually a reversible condition.

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events; ADL: activities of daily living.
* Instrumental ADLs include preparing meals, shopping, using the telephone, managing money. Self-care ADLs include bathing, dressing, using the toilet, taking medications.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).

Graphic 91811 Version 5.0

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NCI CTCAE v5.0 agitation, confusion, delirium