Epithelial carcinoma of the ovary, fallopian tube, and peritoneum: Common immunohistochemical profiles and gene mutations in histologic subtypes

	Common immunoprofile	Common gene mutations
High-grade serous	P53+ WT1+ Pax8+ High Ki67	TP53 BRCA1,2
Low-grade serous	WT1+ Pax8+ p53 wild type Low Ki67	BRAF KRAS
Endometrioid	Estrogen receptor (ER)+ Pax8+ Vimentin+ WT1- p53 wild type	PTEN CTNNB-1 (beta-catenin)
Clear cell	HNF beta+ WT1- ER-	KRAS PTEN PIK3CA
Mucinous	CK20+ cdx2+ CK7+ ER- WT1-	KRAS

Graphic 91891 Version 1.0

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