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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Polycystic ovary syndrome adult phenotypes, in order of decreasing clinical severity

Polycystic ovary syndrome adult phenotypes, in order of decreasing clinical severity
Phenotype A (classic PCOS) Rotterdam criteria, 2003[1]  AES criteria, 2006[2]  NIH criteria, 1992[3]  Classic PCOS[4] 
Clinical and/or biochemical evidence of hyperandrogenism
Evidence of oligo-anovulation
Ultrasonographic evidence of a polycystic ovary
Phenotype B (hyperandrogenic anovulation)  
Clinical and/or biochemical evidence of hyperandrogenism
Evidence of oligo-anovulation
Phenotype C (ovulatory PCOS)  
Clinical and/or biochemical evidence of hyperandrogenism
Ultrasonographic evidence of a polycystic ovary
Phenotype D (nonhyperandrogenic PCOS)  
Evidence of oligo-anovulation
Ultrasonographic evidence of a polycystic ovary
Specification of phenotype was proposed in a workshop convened by the NIH in 2012[5]. The 4 adult phenotypes are listed here in order of decreasing clinical severity and decreasing diagnostic specificity of phenotypes C and D. Each set of diagnostic criteria requires exclusion of other causes of hyperandrogenism and anovulation.
PCOS: polycystic ovary syndrome; AES: Androgen Excess Society; NIH: National Institutes of Health.
References:
  1. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004; 81:19.
  2. Azziz R, Carmina E, Dewailly D, et al. Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab 2006; 91:4237.
  3. Zawadski JK, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: Towards a rational approach. In: Polycystic Ovary Syndrome (Current Issues in Endocrinology and Metabolism), Dunaif A, Givens JR, Haseltine FP, Merriam GE (Eds), Blackwell Scientific Inc., Boston 1992. p.377.
  4. Stein IF, Leventhal ML. Amenorrhea associated with bilateral polycystic ovaries. Am J Obstet Gynecol 1935;29:181-191.
  5. Johnson TRB, Kaplan LK, Ouyang P, Rizza RA. Evidence-based methodology workshop on polycystic ovary syndrome, 2012. Executive Summary. Available at: http://prevention.nih.gov/workshops/2012/pcos/docs/FinalReport.pdf (Accessed on December 24, 2013).
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