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Acetaminophen (paracetamol) and phenylephrine: Drug information

Acetaminophen (paracetamol) and phenylephrine: Drug information
(For additional information see "Acetaminophen (paracetamol) and phenylephrine: Patient drug information" and see "Acetaminophen (paracetamol) and phenylephrine: Pediatric drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Cetafen Cold [OTC];
  • Contac Cold + Flu Maximum Strength Non-Drowsy [OTC];
  • GoodSense Pressure/Pain [OTC];
  • Mapap Sinus PE [OTC];
  • Robitussin Peak Cold Nasal Relief [OTC];
  • Sinus Pain & Pressure [OTC];
  • Tylenol Sinus + Headache [OTC]
Pharmacologic Category
  • Analgesic, Nonopioid;
  • Decongestant
Dosing: Adult
Allergies/common cold/hay fever

Allergies/common cold/hay fever: Oral: Note: OTC dosing recommendations may vary by product and/or manufacturer. When calculating the maximum daily dose, consider all sources of acetaminophen (prescription and OTC) and all routes of administration. Do not exceed the maximum recommended daily dose. No dose adjustment required when converting between different acetaminophen formulations.

Acetaminophen 325 mg/phenylephrine 5 mg: Acetaminophen 650 mg/phenylephrine 10 mg every 4 to 6 hours as needed. Refer to product-specific labeling for maximum daily dosage (maximum dosage range: acetaminophen 2.6 to 3.25 g/phenylephrine 40 to 50 mg per 24 hours).

Acetaminophen 500 mg/phenylephrine 5 mg: Acetaminophen 1 g/phenylephrine 10 mg every 4 to 6 hours as needed; maximum: acetaminophen 4 g/phenylephrine 40 mg per 24 hours.

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling; use with caution. Limited, low-dose therapy is usually well tolerated in hepatic disease/cirrhosis; however, cases of hepatotoxicity at daily acetaminophen dosages <4 g/day have been reported. Avoid chronic use in hepatic impairment. Also see Acetaminophen monograph.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Acetaminophen (paracetamol) and phenylephrine: Pediatric drug information")

Allergies/common cold/hay fever

Allergies/common cold/hay fever:

Note: OTC dosing recommendations may vary by product and/or manufacturer. When calculating the maximum daily dose, consider all sources of acetaminophen (prescription and OTC) and all routes of administration. Do not exceed the maximum recommended daily dose. Multiple formulations of tablet strengths exist; pay close attention to the strength when ordering or administering.

Acetaminophen 325 mg/phenylephrine 5 mg per tablet (eg, Tylenol Sinus + Headache, Sudafed PE Pressure + Pain): Children ≥12 years and Adolescents: Oral: 2 tablets every 4 hours as needed; maximum daily dose range: 10 to 12 tablets/24 hours; maximum daily dose varies by product; see product-specific labeling for details.

Acetaminophen 500 mg/phenylephrine 5 mg per tablet (eg, Contact Cold & Flu Day, Cetafen Cold & Sinus Relief): Children ≥12 years and Adolescents: Oral: 2 tablets every 4 to 6 hours as needed; maximum daily dose: 8 tablets/24 hours.

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling; use with caution. Limited, low-dose therapy is usually well tolerated in hepatic disease/cirrhosis; however, cases of hepatotoxicity at recommended daily acetaminophen dosages have been reported. Avoid chronic use in hepatic impairment. Also see Acetaminophen monograph.

Adverse Reactions

See individual agents.

Contraindications

OTC labeling: When used for self-medication, do not use with any other drug containing acetaminophen; in combination with or within 14 days of stopping a monoamine oxidase inhibitor (MAOI); if you are hypersensitive to acetaminophen, phenylephrine, or any component of the formulation; longer than 10 days (for pain), 3 days (for fever), or 2 days (sore throat).

Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Warnings/Precautions

Concerns related to adverse effects:

• Hepatotoxicity: Acetaminophen has been associated with acute liver failure, at times resulting in liver transplant and death. Hepatotoxicity is usually associated with excessive acetaminophen intake and often involves more than one product that contains acetaminophen. Do not exceed the maximum recommended daily dose (>4 g daily in adults). In addition, long-term daily dosing may also result in liver damage in some patients.

• Skin reactions: Serious and potentially fatal skin reactions, including acute generalized exanthematous pustulosis (AGEP), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN), have occurred rarely with acetaminophen use. Discontinue therapy at the first appearance of skin rash.

• Hypersensitivity/anaphylactic reactions: Hypersensitivity and anaphylactic reactions have been reported; discontinue immediately if symptoms of allergic or hypersensitivity reactions occur.

Disease-related concerns:

• Cardiovascular disease: Use with caution in patients with cardiovascular disease (including hypertension and ischemic heart disease).

• Diabetes: Use with caution in patients with diabetes mellitus.

• Ethanol use: Use with caution in patients with alcoholic liver disease; consuming ≥3 alcoholic drinks/day may increase the risk of liver damage. Avoid ethanol or limit to <3 alcoholic drinks/day.

• G6PD deficiency: Use with caution in patients with known G6PD deficiency.

• Hepatic impairment: Use with caution in patients with hepatic impairment or active liver disease.

• Prostatic hyperplasia/urinary obstruction: Use with caution in patients with prostatic hyperplasia and/or GU obstruction.

• Thyroid dysfunction: Use with caution in patients with thyroid dysfunction.

Special populations:

• Older adult: Use with caution in the elderly; more likely to experience adverse reactions to sympathomimetics.

Other warnings/precautions:

• Dosage limit: Limit acetaminophen dose from all sources <4 g/day (adults).

• Self-medication (OTC use): When used for self-medication (OTC), discontinue use and notify health care provider if pain or nasal congestion does not improve or gets worse within 7 days or are accompanied by fever; fever gets worse or lasts >3 days; if any new symptoms or nervousness, dizziness, or sleeplessness occur; or if redness or swelling is present. If sore throat persists for >2 days, is accompanied or followed by a fever, headache, rash, nausea, or vomiting, contact health care provider.

Warnings: Additional Pediatric Considerations

Hepatoxicity has been reported in patients using acetaminophen. In pediatric patients, this is most commonly associated with supratherapeutic dosing, more frequent administration than recommended, and use of multiple acetaminophen-containing products; however, hepatotoxicity has been rarely reported with recommended dosages (AAP [Sullivan 2011]; Heard 2014). All sources of acetaminophen (eg, prescription, OTC, combination) should be considered when evaluating a patient's maximum daily dose. To lower the risk for hepatotoxicity, the maximum daily acetaminophen dose should be limited to ≤75 mg/kg/day (maximum of 5 daily doses), not to exceed 4,000 mg/day (AAP [Sullivan 2011]; Heard 2014; Krenzelok 2012; Lavonas 2010). Acetaminophen avoidance or a lower total daily dose (2,000 to 3,000 mg/day) has been suggested for adults with increased risk for acetaminophen hepatotoxicity (eg, malnutrition, certain liver diseases, use of drugs that interact with acetaminophen metabolism); similar data are unavailable in pediatric patients (Hayward 2016; Larson 2007; Worriax 2007).

Safety and efficacy for the use of cough and cold products in pediatric patients <4 years of age is limited; the AAP warns against the use of these products for respiratory illnesses in young children. Serious adverse effects including death have been reported (in some cases, high blood concentrations of pseudoephedrine were found). Many of these products contain multiple active ingredients, increasing the risk of accidental overdose when used with other products. The FDA does not recommend OTC uses for these products in pediatric patients <2 years of age and recommends to use with caution in pediatric patients ≥2 years of age. Health care providers are reminded to ask caregivers about the use of OTC cough and cold products in order to avoid exposure to multiple medications containing the same ingredient (AAP 2018; CDC 2007; FDA 2017; FDA 2018). Multiple formulations of tablet strengths exist; pay close attention to the strength when ordering or administering.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product.

Caplet, oral:

Contac Cold + Flu Maximum Strength Non Drowsy: Acetaminophen 500 mg and phenylephrine hydrochloride 5 mg

Mapap Sinus PE, Sudafed PE Pressure + Pain: Acetaminophen 325 mg and phenylephrine hydrochloride 5 mg

Tylenol Sinus + Headache: Acetaminophen 325 mg and phenylephrine hydrochloride 5 mg

Tablet, oral:

Cetafen Cold: Acetaminophen 500 mg and phenylephrine hydrochloride 5 mg

GoodSense Pressure/Pain PE: Acetaminophen 325 mg and phenylephrine hydrochloride 5 mg

Robitussin Peak Cold Nasal Relief: Acetaminophen 325 mg and phenylephrine hydrochloride 5 mg

Sinus Pain & Pressure: Acetaminophen 500 mg and phenylephrine hydrochloride 5 mg

Generic: Acetaminophen 325 mg and phenylephrine hydrochloride 5 mg

Generic Equivalent Available: US

Yes: Caplet, tablet

Pricing: US

Tablets (Panadol Cold/Flu Oral)

5-325 mg (per each): $0.27

Tablets (Sudafed PE Sinus Pressure+Pain Oral)

5-325 mg (per each): $0.29

Tablets (Tylenol Sinus+Headache Oral)

5-325 mg (per each): $0.30

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Adult

Swallow caplets, gelcaps, and liquid-filled capsules whole; do not crush, chew, or dissolve.

Administration: Pediatric

Oral: Swallow caplets whole; do not crush, chew, or dissolve.

Use: Labeled Indications

Allergies/common cold/hay fever: Temporary relief of symptoms (nasal congestion, sinus congestion/pressure, minor aches and pain, headache, fever, sore throat) associated with hay fever, other respiratory allergies, and the common cold.

Medication Safety Issues
Other safety concerns:

Duplicate therapy issues: This product contains acetaminophen, which may be a component of combination products. Do not exceed the maximum recommended daily dose of acetaminophen.

Metabolism/Transport Effects

Refer to individual components.

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.

Acetaminophen: May increase the serum concentration of Phenylephrine (Systemic). Risk C: Monitor therapy

Alcohol (Ethyl): May enhance the hepatotoxic effect of Acetaminophen. Risk C: Monitor therapy

Alpha1-Blockers: May diminish the vasoconstricting effect of Alpha1-Agonists. Similarly, Alpha1-Agonists may antagonize Alpha1-Blocker vasodilation. Risk C: Monitor therapy

Atomoxetine: May enhance the hypertensive effect of Sympathomimetics. Atomoxetine may enhance the tachycardic effect of Sympathomimetics. Risk C: Monitor therapy

Atropine (Systemic): May enhance the hypertensive effect of Alpha1-Agonists. Risk C: Monitor therapy

Benzylpenicilloyl Polylysine: Alpha1-Agonists may diminish the diagnostic effect of Benzylpenicilloyl Polylysine. Management: Consider delaying skin testing until alpha1-agonists are no longer required, or use of a histamine skin test as a positive control to assess a patient's ability to mount a wheal and flare response. Risk D: Consider therapy modification

Bromocriptine: May enhance the hypertensive effect of Alpha1-Agonists. Management: Consider alternatives to this combination when possible. If combined, monitor for hypertension and tachycardia, and do not coadminister these agents for more than 10 days. Risk D: Consider therapy modification

Busulfan: Acetaminophen may increase the serum concentration of Busulfan. Risk C: Monitor therapy

Cannabinoid-Containing Products: May enhance the tachycardic effect of Sympathomimetics. Risk C: Monitor therapy

CarBAMazepine: May increase the metabolism of Acetaminophen. This may 1) diminish the effect of acetaminophen; and 2) increase the risk of liver damage. Risk C: Monitor therapy

Chloroprocaine (Systemic): May enhance the hypotensive effect of Phenylephrine (Systemic). Risk C: Monitor therapy

CloZAPine: May diminish the therapeutic effect of Phenylephrine (Systemic). Risk C: Monitor therapy

Cocaine (Topical): May enhance the hypertensive effect of Sympathomimetics. Management: Consider alternatives to use of this combination when possible. Monitor closely for substantially increased blood pressure or heart rate and for any evidence of myocardial ischemia with concurrent use. Risk D: Consider therapy modification

Dapsone (Topical): May enhance the adverse/toxic effect of Methemoglobinemia Associated Agents. Risk C: Monitor therapy

Dasatinib: Acetaminophen may enhance the hepatotoxic effect of Dasatinib. Dasatinib may increase the serum concentration of Acetaminophen. Management: Avoid coadministration of acetaminophen and dasatinib if possible. If coadministration is unavoidable, monitor for signs/symptoms of hepatotoxicity, particularly in patients with greater acetaminophen exposure. Risk D: Consider therapy modification

Doxofylline: Sympathomimetics may enhance the adverse/toxic effect of Doxofylline. Risk C: Monitor therapy

Ergot Derivatives (Vasoconstrictive CYP3A4 Substrates): May enhance the vasoconstricting effect of Alpha1-Agonists. Risk X: Avoid combination

FentaNYL: Decongestants may decrease the serum concentration of FentaNYL. Risk C: Monitor therapy

Flucloxacillin: May enhance the adverse/toxic effect of Acetaminophen. Specifically, the risk for high anion gap metabolic acidosis may be increased. Risk C: Monitor therapy

Fosphenytoin-Phenytoin: May decrease the serum concentration of Acetaminophen. Specifically, serum concentrations of acetaminophen may be decreased (leading to decreased efficacy), but the formation of the toxic N-acetyl-p-benzoquinone imine (NAPQI) metabolite may be increased (leading to increased hepatotoxicity). Risk C: Monitor therapy

Guanethidine: May enhance the arrhythmogenic effect of Sympathomimetics. Guanethidine may enhance the hypertensive effect of Sympathomimetics. Risk C: Monitor therapy

Hyaluronidase: May enhance the vasoconstricting effect of Phenylephrine (Systemic). Management: Do not use hyaluronidase to enhance the dispersion or absorption of phenylephrine. Use of hyaluronidase for other purposes in patients receiving phenylephrine may be considered as clinically indicated. Risk D: Consider therapy modification

Imatinib: Acetaminophen may enhance the hepatotoxic effect of Imatinib. Risk C: Monitor therapy

Immune Checkpoint Inhibitors (Anti-PD-1, -PD-L1, and -CTLA4 Therapies): Acetaminophen may diminish the therapeutic effect of Immune Checkpoint Inhibitors (Anti-PD-1, -PD-L1, and -CTLA4 Therapies). Risk C: Monitor therapy

Iobenguane Radiopharmaceutical Products: Alpha1-Agonists may diminish the therapeutic effect of Iobenguane Radiopharmaceutical Products. Management: Discontinue all drugs that may inhibit or interfere with catecholamine transport or uptake for at least 5 biological half-lives before iobenguane administration. Do not administer these drugs until at least 7 days after each iobenguane dose. Risk X: Avoid combination

Isoniazid: May enhance the hepatotoxic effect of Acetaminophen. Isoniazid may increase the metabolism of Acetaminophen. Specifically, formation of the hepatotoxic NAPQI metabolite may be increased. Risk C: Monitor therapy

Kratom: May enhance the adverse/toxic effect of Sympathomimetics. Risk X: Avoid combination

LamoTRIgine: Acetaminophen may decrease the serum concentration of LamoTRIgine. Risk C: Monitor therapy

Levothyroxine: May enhance the adverse/toxic effect of Sympathomimetics. Specifically, the risk of coronary insufficiency may be increased in patients with coronary artery disease. Levothyroxine may enhance the therapeutic effect of Sympathomimetics. Sympathomimetics may enhance the therapeutic effect of Levothyroxine. Risk C: Monitor therapy

Linezolid: May enhance the hypertensive effect of Sympathomimetics. Management: Consider initial dose reductions of sympathomimetic agents, and closely monitor for enhanced blood pressure elevations, in patients receiving linezolid. Risk D: Consider therapy modification

Lisuride: May enhance the hypertensive effect of Alpha1-Agonists. Risk X: Avoid combination

Local Anesthetics: Methemoglobinemia Associated Agents may enhance the adverse/toxic effect of Local Anesthetics. Specifically, the risk for methemoglobinemia may be increased. Risk C: Monitor therapy

Lorlatinib: May decrease the serum concentration of Acetaminophen. Risk C: Monitor therapy

MetyraPONE: May increase the serum concentration of Acetaminophen. More importantly, by inhibiting the conjugative metabolism of acetaminophen, metyrapone may shift the metabolism towards the oxidative route that produces a hepatotoxic metabolite. Risk X: Avoid combination

Mipomersen: Acetaminophen may enhance the hepatotoxic effect of Mipomersen. Risk C: Monitor therapy

Mitapivat: May decrease the serum concentration of UGT1A1 Substrates. Risk C: Monitor therapy

Monoamine Oxidase Inhibitors: May enhance the hypertensive effect of Alpha1-Agonists. While linezolid is expected to interact via this mechanism, management recommendations differ from other monoamine oxidase inhibitors. Refer to linezolid specific monographs for details. Risk X: Avoid combination

Nitric Oxide: May enhance the adverse/toxic effect of Methemoglobinemia Associated Agents. Combinations of these agents may increase the likelihood of significant methemoglobinemia. Risk C: Monitor therapy

Ozanimod: May enhance the hypertensive effect of Sympathomimetics. Risk C: Monitor therapy

Pergolide: May enhance the hypertensive effect of Alpha1-Agonists. Risk C: Monitor therapy

PHENobarbital: May increase the metabolism of Acetaminophen. Specifically, formation of the hepatotoxic NAPQI metabolite may be increased. Risk C: Monitor therapy

Phenylephrine (Systemic): Acetaminophen may increase the serum concentration of Phenylephrine (Systemic). Risk C: Monitor therapy

Prilocaine: Methemoglobinemia Associated Agents may enhance the adverse/toxic effect of Prilocaine. Combinations of these agents may increase the likelihood of significant methemoglobinemia. Management: Monitor patients for signs of methemoglobinemia (e.g., hypoxia, cyanosis) when prilocaine is used in combination with other agents associated with development of methemoglobinemia. Avoid lidocaine/prilocaine in infants receiving such agents. Risk C: Monitor therapy

Primidone: May increase the metabolism of Acetaminophen. Specifically, formation of the hepatotoxic NAPQI metabolite may be increased. Risk C: Monitor therapy

Probenecid: May increase the serum concentration of Acetaminophen. Probenecid may also limit the formation of at least one major non-toxic metabolite, possibly increasing the potential for formation of the toxic NAPQI metabolite. Management: Consider limiting acetaminophen use in combination with probenecid. Probenecid may reduce clearance of acetaminophen to one of its non-toxic metabolities, increasing the risk for acetaminophen toxicity, even a lower doses. Risk D: Consider therapy modification

Propacetamol: May increase the serum concentration of Phenylephrine (Systemic). Management: Monitor patients closely for increased side effects of phenylephrine if propacetamol is used concomitantly. Patients with underlying blood pressure issues or arrhythmias may need closer monitoring and may warrant consideration of alternative therapies. Risk C: Monitor therapy

RifAMPin: May enhance the hepatotoxic effect of Acetaminophen. RifAMPin may decrease the serum concentration of Acetaminophen. Risk C: Monitor therapy

Sodium Nitrite: Methemoglobinemia Associated Agents may enhance the adverse/toxic effect of Sodium Nitrite. Combinations of these agents may increase the likelihood of significant methemoglobinemia. Risk C: Monitor therapy

Solriamfetol: Sympathomimetics may enhance the hypertensive effect of Solriamfetol. Sympathomimetics may enhance the tachycardic effect of Solriamfetol. Risk C: Monitor therapy

SORAfenib: Acetaminophen may enhance the hepatotoxic effect of SORAfenib. SORAfenib may increase the serum concentration of Acetaminophen. Management: Avoid coadministration of acetaminophen and sorafenib if possible. If coadministration is unavoidable, monitor for signs/symptoms of hepatotoxicity, particularly in patients with greater acetaminophen exposure. Risk D: Consider therapy modification

Sympathomimetics: May enhance the adverse/toxic effect of other Sympathomimetics. Risk C: Monitor therapy

Tedizolid: May enhance the hypertensive effect of Sympathomimetics. Tedizolid may enhance the tachycardic effect of Sympathomimetics. Risk C: Monitor therapy

Tricyclic Antidepressants: May enhance the therapeutic effect of Alpha1-Agonists. Tricyclic Antidepressants may diminish the therapeutic effect of Alpha1-Agonists. Risk C: Monitor therapy

Vaccines: Acetaminophen may diminish the therapeutic effect of Vaccines. Management: Consider avoiding routine prophylactic use of acetaminophen before or during vaccine administration when possible. Acetaminophen is still recommended to treat fevers and/or pain that occurs after vaccination. Risk D: Consider therapy modification

Vitamin K Antagonists (eg, warfarin): Acetaminophen may enhance the anticoagulant effect of Vitamin K Antagonists. This appears most likely with daily acetaminophen doses exceeding 1.3 or 2 g/day for multiple consecutive days. Risk C: Monitor therapy

Pregnancy Considerations

Refer to individual monographs.

Breastfeeding Considerations

Refer to individual monographs.

Dietary Considerations

Some products may contain phenylalanine and/or sodium.

Mechanism of Action

Acetaminophen: Although not fully elucidated, the analgesic effects are believed to be due to activation of descending serotonergic inhibitory pathways in the CNS. Interactions with other nociceptive systems may be involved as well (Smith 2009). Antipyresis is produced from inhibition of the hypothalamic heat-regulating center.

Phenylephrine: Causes vasoconstriction of the arterioles of the nasal mucosa.

Pharmacokinetics (Adult Data Unless Noted)

See individual agents.

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AR) Argentina: Desenfriol descongestivo | Dristan descongestivo | Duflegrip free | Gripaben descongestivo | Itedal plus | Kroltonex;
  • (AU) Australia: Aft pharmaceuticals cold & flu relief | AMCAL SINUS PAIN RELIEF PE | Chemists Own Sinus Pain Relief PE | Chemists' own cold & flu relief pe | Chemists' own day + night cold & flu relief pe | Chemists' own sinus pain relief pe | Cip cold & flu day and night tablets | Cipla sinus pain relief pe day | Codral cold & flu | Codral day & night | Codral relief cold & flu + decongestant | Cold & Flu Relief PE | Coles cold & flu pain relief + pe decongestant | Demazin cold + flu relief day + night | Demazin pe multi action cold & flu relief | Demazin pe multi action cold&flu relief | Dimetapp pe sinus pain | Easeacold paracetamol & phenylephrine cold, flu + decongestant | Hedanol cold & flu decongestant with pain relief | Help@hand for cold & flu relief | Maxiclear cold & flu relief | Maxiclear cold & flu relief sinus & pain relief | Maxiclear Sinus & Pain Relief | Medi cold cold, flu + decongestant | Medichoice cold & flu + pain relief pe | Medix cold & flu + pain relief pe | Medix nasal decongestant + pain relief pe | Medix sinus + pain relief pe | Nyal cold and flu | Nyal sinus + pain relief pe | Panadol cold & flu plus decongestant | Panadol sinus pain & congestion relief | Panadol sinus pain & congestion relief day & night | Paraphen | Pharmacy action cold & flu pe | Pharmacy care sinus pain relief pe | Pharmacy choice cold & flu + sinus pe | Pharmacy choice sinus pain relief pe | Pharmacy health cold & flu relief pe | Priceline cold & flu relief pe | Priceline sinus pe | Robitussin cold & flu + decongestant | Robitussin head cold & sinus | Sinus pain relief PE | Soul pattinson cold & flu relief pe | Sudafed pe sinus + pain relief | Terrywhite chemmart cold & flu relief pe | Trust sinus pain relief pe | Vicks ActionCold & Flu Day Relief | Vidalife cold & flu pe | Your Pharmacy Head Cold Relief | Your pharmacy sinus pain relief;
  • (BR) Brazil: Benegrip multi dia | Corizz Dia | Fluviral dia | Gripen dia | Naldecon dia | Naldecon multi | Neolefrin dia;
  • (CO) Colombia: Pax dia | Refritab | Sinutab plus ns;
  • (DE) Germany: Doregrippin;
  • (HK) Hong Kong: Coltalin-Nd;
  • (ID) Indonesia: Bodrex flu;
  • (MX) Mexico: Flusiquim | Tempra xt dia | Theraflu td;
  • (MY) Malaysia: Panadol cold flu nd;
  • (NZ) New Zealand: Codral cold & flu | Pharmacy health Cold & Flu Day + Night PE;
  • (PE) Peru: Vitapyrena plus;
  • (PH) Philippines: Analem | Nasatapp no drowse;
  • (PL) Poland: Gripex duo;
  • (PR) Puerto Rico: Acetaminophen congestion and pain | Panadol cold & flu nondrowsy | Sinutab sinus;
  • (PT) Portugal: Antigrippine trieffect;
  • (QA) Qatar: Lemsip Cold and Flu with Decongestant | Panadol Cold and Flu Vapour Release plus Decongestant | Panadol Sinus Relief PE | Panda Zokam;
  • (SG) Singapore: Decolgen Non Drowse | Panadol Sinus Max;
  • (VN) Viet Nam: Hapacol cs day;
  • (ZA) South Africa: Dristan cold nd
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  23. Mehlisch DR, Aspley S, Daniels SE, et al. Comparison of the Analgesic Efficacy of Concurrent Ibuprofen and Paracetamol With Ibuprofen or Paracetamol Alone in the Management of Moderate to Severe Acute Postoperative Dental Pain in Adolescents and Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Single-Dose, Two-Center, Modified Factorial Study. Clin Ther. 2010;32(5):882-895. [PubMed 20685496]
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  25. QlearQuil Daytime Sinus and Congestion (acetaminophen/phenylephrine) [prescribing information]. Cincinnati, OH: Procter & Gamble; no date.
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Topic 9232 Version 196.0

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