Note: Eurax cream and lotion have been discontinued in the US for >1 year.
Pruritus: Topical: Massage into affected areas until medication is completely absorbed; repeat as necessary
Scabies: Topical: Apply a thin layer and massage drug onto skin of the entire body from the neck to the toes (with special attention to skin folds, creases, and interdigital spaces). Repeat application in 24 hours. May re-treat if new lesions appear or itching persists more than 2 to 4 weeks after initial treatment (CDC 2018).
There are no dosage adjustments provided in manufacturer's labeling.
There are no dosage adjustments provided in manufacturer's labeling.
Refer to adult dosing.
(For additional information see "Crotamiton: Pediatric drug information")
Note: Eurax cream and lotion have been discontinued in the United States for >1 year.
Scabies (alternative agent): Limited data available; recommended regimens variable:
AAP recommendations: Infants, Children, and Adolescents: Topical: Apply a thin layer onto skin of entire body from neck to toes overnight for 3 consecutive nights (days 1 through 3) and again on day 8 (Bradley 2022; Red Book [AAP 2021]). Shorter durations of 2 consecutive nights have also been reported (Amer 1992; Bernigaud 2020; Diiorio 2020).
5-day regimen:
Infants ≥2 months and Children <2 years: Topical: Apply a thin layer onto skin of entire body from neck to toes once daily for 5 consecutive days without bathing or washing cream off until 24 hours after last application (Cubela 1978; Hay 2012; Konstantinov 1979).
Children ≥2 years and Adolescents: Topical: Apply a thin layer onto skin of entire body from neck to toes once or twice daily for 5 consecutive days (Goldust 2014; Hay 2012; Pourhasan 2013).
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
The following adverse drug reactions are derived from product labeling unless otherwise specified.
Postmarketing:
Dermatologic: Dermal ulcer (anogenital) (Handa 2022), dermatitis, purpuric rash (anogenital) (Handa 2022), skin necrosis (anogenital) (Handa 2022), skin rash
Hypersensitivity: Hypersensitivity reaction
Hypersensitivity to crotamiton or any component of the formulation; patients who manifest a primary irritation response to topical medications
Other warnings/precautions:
• Appropriate use: For external use only; avoid contact with face, eyes, mucous membranes, and urethral meatus. Do not apply to acutely inflamed, raw, or weeping skin. Discontinue use if severe irritation or sensitization occurs.
Some dosage forms may contain propylene glycol; in neonates large amounts of propylene glycol delivered orally, intravenously (eg, >3,000 mg/day), or topically have been associated with potentially fatal toxicities which can include metabolic acidosis, seizures, renal failure, and CNS depression; toxicities have also been reported in children and adults including hyperosmolality, lactic acidosis, seizures, and respiratory depression; use caution (AAP 1997; Shehab 2009).
Eurax cream and lotion have been discontinued in the US for >1 year.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Lotion, External:
Crotan: 10% (60 g, 237 g, 454 g) [contains benzyl alcohol, cetyl alcohol, propylene glycol]
No
Lotion (Crotan External)
10% (per gram): $8.10
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Topical: For external use only; avoid eyes and mucous membranes. Shake lotion well before using. Take a bath or shower prior to application. Apply from neck down to toes. Trim fingernails and apply under nails (can use toothbrush, which should be disposed of after use). Take a cleansing bath 48 hours after the final application. Contaminated clothing and bed linens should be washed on hot cycle or dry-cleaned and all clothing and bedding should be changed the day after application.
Topical: For external use only; avoid eyes and mucous membranes. Shake lotion well before using. Take a bath or shower prior to application and towel dry skin; apply a thin layer and gently massage drug onto skin of the entire body from the neck to the toes (with special attention to skin folds, creases, and interdigital spaces); also apply under fingernails after trimming nails short (can use toothbrush to apply under nails; dispose of toothbrush after use). Because scabies can affect the head, scalp, and neck in infants and young children, apply to scalp, neck, and body of this age group (Diiorio 2020; Red Book [AAP 2021]). Take a cleansing bath 24 to 48 hours after the final application (Diiorio 2020; manufacturer's labeling). Contaminated clothing and bed linens should be washed on a hot cycle or dry-cleaned and all clothing and bedding should be changed the day after treatment is completed.
Treatment of scabies (Sarcoptes scabiei) and symptomatic treatment of pruritus
Eurax may be confused with Efudex, Eulexin, Evoxac, Serax, Urex
Eurax [US, Canada, and multiple international markets] may be confused with Urex brand name for furosemide [Australia, China, Turkey] and methenamine [US, Canada]
None known.
There are no known significant interactions.
Animal reproduction studies have not been conducted; use during pregnancy only if clearly needed.
It is not known if crotamiton is excreted in breast milk.
Crotamiton has scabicidal activity against Sarcoptes scabiei; mechanism of action unknown. Antipruritic effects mediated by inhibition of histamine, serotonin, and PAR-2 (Sekine 2012).
Absorption: Amount of systemic absorption following topical use has not been determined
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