ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
medimedia.ir

Acetylcholine chloride intraocular solution: Drug information

Acetylcholine chloride intraocular solution: Drug information
(For additional information see "Acetylcholine chloride intraocular solution: Patient drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Miochol-E
Brand Names: Canada
  • Miochol-E
Pharmacologic Category
  • Cholinergic Agonist;
  • Ophthalmic Agent, Miotic
Dosing: Adult
Ophthalmic surgery

Ophthalmic surgery: Intraocular: Usual dosage: 0.5 to 2 mL.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Older Adult

Refer to adult dosing.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.

Cardiovascular: Bradycardia, flushing, hypotension

Dermatologic: Diaphoresis

Ophthalmic: Cloudy vision, corneal decompensation, corneal edema

Respiratory: Dyspnea

Contraindications

Hypersensitivity to acetylcholine chloride or any component of the formulation

Warnings/Precautions

Disease-related concerns:

• Diseases affected by systemic effects: Systemic effects rarely occur but can cause problems for patients with asthma, GI spasm, acute heart failure, hyperthyroidism, Parkinson's disease, peptic ulcer disease, and or urinary tract obstruction. In a scientific statement from the American Heart Association, ophthalmic cholinergic agents have been determined to be agents that may exacerbate underlying myocardial dysfunction (magnitude: minor) (AHA [Page 2016]).

Other warnings/precautions:

• Aseptic conditions: Open under aseptic conditions only; do not gas sterilize.

• Cataract surgery: During cataract surgery, use only after lens is in place.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution Reconstituted, Intraocular, as chloride:

Miochol-E: 20 mg (1 ea) [contains mannitol]

Generic Equivalent Available: US

No

Pricing: US

Solution (reconstituted) (Miochol-E Intraocular)

20 mg (per each): $154.37

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution Reconstituted, Intraocular, as chloride:

Miochol-E: 20 mg (2 mL)

Administration: Adult

Ophthalmic: Open under aseptic conditions only. Attach filter before irrigating eye. Instill into anterior chamber before or after securing one or more sutures; instillation should be gentle and parallel to the iris face and tangential to the pupil border; in cataract surgery, acetylcholine should be used only after delivery of the lens.

Use: Labeled Indications

Ophthalmic surgery: To obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy, and other anterior segment surgery where rapid miosis may be required

Medication Safety Issues
Sound-alike/look-alike issues:

Acetylcholine may be confused with acetylcysteine

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Mechanism of Action

Causes contraction of the sphincter muscles of the iris, resulting in miosis and contraction of the ciliary muscle, leading to accommodation spasm

Pharmacokinetics (Adult Data Unless Noted)

Onset of action: Rapid

Duration: ~20 minutes (Kanski 1968); duration as long as 6 hours has been reported (Roszkowska 1998)

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (FI) Finland: Miochol e;
  • (QA) Qatar: Miochol-E
  1. Kanski JJ. Miotics, Br J Ophthalmol. 1968;52(12):936-937.
  2. Miochol E (acetylcholine chloride) [product monograph]. Bridgewater, NJ: Bausch & Lomb Americas Inc; March 2023.
  3. Page RL 2nd, O'Bryant CL, Cheng D, et al; American Heart Association Clinical Pharmacology and Heart Failure and Transplantation Committees of the Council on Clinical Cardiology; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular and Stroke Nursing; and Council on Quality of Care and Outcomes Research. Drugs That May Cause or Exacerbate Heart Failure: A Scientific Statement From the American Heart Association [published correction appears in Circulation. 2016;134(12):e261]. Circulation. 2016;134(6):e32-e69. [PubMed 27400984]
  4. Roszkowska AM, Ferreri G, Squeri CA, et al, "Effect of Intraocular Acetylcholine and Carbachol on the Corneal Endothelium. In vivo Comparative Study," Ophthalmologica. 1998;212(6):407-409. [PubMed 9787232]
Topic 9303 Version 140.0

آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟