Recommended doses (mg/day) of statins for treatment of adults with CKD

Doses shown may differ from recommendations in approved product information for use in patients with kidney function impairment and are based on regimens shown to be beneficial in randomized trials conducted in patients with CKD; refer to UpToDate content on CKD. Lower doses than those used in major trials of statins in CKD populations may be appropriate for patients of Asian ancestry. Note that rosuvastatin 40 mg daily is not recommended for use in CKD G1 to G2 nontransplant patients, as it may increase the risk of adverse kidney events. Cyclosporine inhibits the metabolism of certain statins, resulting in higher blood levels, and some combinations are contraindicated. To determine specific interactions, use the Lexi-Interact program included with UpToDate.