| Generic name | United States brand name | How taken | Risks and side effects | Other |
| Imatinib | Gleevec | Daily (or twice daily) with food | - Low blood counts (increased infection)
- Swelling and fluid retention
- Diarrhea
- Rash
- Fatigue
- Muscle cramps
- Heart damage (uncommon)
- Liver damage (uncommon)
| Most long-term safety data |
| Nilotinib | Tasigna | Twice daily without food | - Low blood counts (increased infection)
- Rash, itching
- Abnormal heart rhythm (called QT prolongation)
- Heart attack, stroke, and related events
- Electrolyte imbalance
- Liver damage
- Pancreatitis (inflammation of the pancreas that can cause stomach pain)
| |
| Dasatinib | Sprycel | Daily with or without food | - Low blood counts (increased infection and fatigue)
- Pleural or pericardial effusions (fluid around the lung or heart)
- Pulmonary hypertension (high blood pressure in the blood vessels that carry blood to the lungs; uncommon)
- Abnormal heart rhythm (called QT prolongation)
- Easy bleeding and bruising
- Headache
| |
| Bosutinib | Bosulif | Daily with food | - Low blood counts (increased infection and fatigue)
- Fever, fatigue, headache
- Swelling and fluid retention
- Diarrhea, nausea, vomiting
- Liver damage
| |
| Ponatinib | Iclusig | Daily with or without food | - Low blood counts (increased infection and fatigue)
- Swelling and fluid retention
- Nausea, vomiting, diarrhea
- Heart failure
- High blood pressure
- Pancreatitis (inflammation of the pancreas that can cause stomach pain)
- Easy bleeding and bruising
- Heart attack, stroke, and related events
- Liver toxicity
| Active against BCR::ABL1 T315I mutation; limited long-term safety data |
| Asciminib | Scemblix | Daily or twice daily without food | - Upper respiratory tract infections
- Muscle and joint pain
- Fatigue
- Low blood counts
- Pancreatitis (inflammation of the pancreas)
- Liver damage
- Nausea
- Diarrhea
| Active against BCR::ABL1 T315I mutation; limited long-term safety data |
