Nomogram predicting the outcome of early salvage radiotherapy

(A) Nomogram to predict the probability of biochemical recurrence (BCR) at 5-yr following early salvage radiotherapy (eSRT) for BCR after radical prostatectomy based on pathologic Gleason score, surgical margin status, and prostate-specific antigen at time of eSRT. Instructions: Locate the patient's pathologic Gleason score on the pathologic Gleason score axis. Draw a line straight upwards to the point axis to determine how many points towards the probability of BCR after eSRT the patient receives for his pathologic Gleason score. Repeat the process for each additional variable. Sum the points for each of the predictors. Locate the final sum on the total-point axis. Draw a line straight down to find the patient's probability of BCR at 5-yr after eSRT.
(B) Nomogram calibration plot for nomogram predicting 5-yr BCR. Perfect predictions correspond to the 45° line. Points estimated below the 45° line correspond to nomogram overprediction, whereas points situated above the 45° line correspond to nomogram underprediction. Vertical lines indicate the frequency distribution of predicted probabilities.
(C) Decision curve analyses demonstrating the net benefit associated with the use of the nomogram. Net benefit can be interpreted as the proportion of all patients who have BCR after eSRT and are recommended for additional cancer therapies if no patients without BCR were treated.