Version May 2024
Otitis externa, acute: Otic: Insert saturated wick of cotton; keep moist for 24 hours by adding 3 to 5 drops every 4 to 6 hours. Remove wick after 24 hours and instill 5 drops 3 to 4 times daily. Treatment duration is usually 7 days and may be extended an additional 7 days if symptoms are improving but not yet resolved (Ref).
There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.
There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.
Refer to adult dosing.
(For additional information see "Acetic acid and hydrocortisone otic: Pediatric drug information")
Otitis externa, acute: Children ≥3 years and Adolescents: Otic: Insert saturated wick of cotton; keep moist 24 hours by adding 3 to 5 drops every 4 to 6 hours; remove wick after 24 hours and instill 5 drops 3 to 4 times daily. Note: In children, 3 to 4 drops may be sufficient due to the smaller capacity of the ear canal.
Children ≥3 years and Adolescents: There are no dosing adjustments provided in the manufacturer's labeling.
Children ≥3 years and Adolescents: There are no dosing adjustments provided in the manufacturer's labeling.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.
Otic: Stinging of ear (includes burning sensation; may occasionally occur when first instilled into acutely inflamed ear)
Hypersensitivity to acetic acid, propylene glycol, hydrocortisone, or any component of the formulation; perforated tympanic membrane; herpes simplex; vaccinia, and varicella
Concerns related to adverse effects:
• Local reaction: Transient stinging or burning may occur when first used in inflamed ear. Discontinue if sensitization or irritation occurs.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Solution, otic [drops]: Acetic acid 2%, propylene glycol diacetate 3%, and hydrocortisone 1% (10 mL)
Acetasol HC: Acetic acid 2%, propylene glycol diacetate 3%, and hydrocortisone 1% (10 mL) [contains benzethonium chloride]
Yes
Solution (Hydrocortisone-Acetic Acid Otic)
1-2% (per mL): $22.58
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Otic: For otic use only. After removing cerumen and debris, saturate a cotton wick with the solution and insert into the ear canal (alternatively, wick may be saturated after insertion). Wick should remain in place for ≥24 hours and then removed; however, drops should continue to be instilled into ear canal as long as indicated.
Otic: Not for internal intake; topical otic use only; prior to use, warm suspension by holding bottle in hands; shake well before use; patient should lie with affected ear upward for instillation
Otitis externa, acute: Treatment of superficial infections of the external auditory canal caused by organisms susceptible to the action of the antimicrobial, complicated by swelling.
VoSol may be confused with Vexol
Refer to individual components.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.
Calcipotriene: Hydrocortisone (Topical) may diminish the therapeutic effect of Calcipotriene. Management: Monitor for reduced calcipotriene efficacy if combined with hydrocortisone valerate. Consider separating the administration of these agents by 10 to 12 hours to minimize the risk of this potential interaction. Risk C: Monitor therapy
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