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PCC products available in the United States

PCC products available in the United States
Unactivated prothrombin complex concentrates (PCCs)
4 factor:*
  • Kcentra
  • Balfaxar

Contain inactive forms of 4 factors: Factors II, VII, IX, and X

Also contain heparin
3 factor:
  • Profilnine

Contains inactive forms of 3 factors: Factors II, IX, and X

Contains little or no factor VII

Does not contain heparin
Activated prothrombin complex concentrate (aPCC)
4 factor:
  • FEIBA

Contains 4 factors: Factors II, VII, IX, and X. Of these, only factor VII is mostly the activated form

Does not contain heparin
The table lists 4-factor and 3-factor PCC products available in the United States. Potency is determined differently for different products; refer to product information. All PCCs are plasma derived and contain other proteins, including anticoagulant proteins (proteins C and S). Unactivated factors are proenzymes (inactive precursor proteins). Activated factors have higher enzymatic activity. Refer to UpToDate topics for use of these products.

FEIBA: factor eight inhibitor bypassing activity; PCC: prothrombin complex concentrate; US: United States.

* Kcentra is available as Beriplex or Confidex in other countries. Balfaxar is available as Octaplex in other countries.

¶ Single-factor recombinant activated factor VII (rFVIIa) products are also available.
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