Common active ingredients of orally administered over-the-counter cough and cold preparations*

Ingredient	Typical single adult dose	Typical single pediatric dose
Antihistamine
First generation
Brompheniramine	4 mg	1 mg
Diphenhydramine	25 mg	1 to 1.25 mg/kg up to 25 mg
Chlorpheniramine	2 to 4 mg	1 to 2 mg
Doxylamine	6.25 to 12.5 mg	2.5 to 6.25 mg
Clemastine	1 to 2 mg (base)	0.5 to 1 mg (base)
Dimenhydrinate	50 mg	1.25 mg/kg up to 25 mg
Triprolidine	2.5 mg	1.25 mg
Second generation
Loratadine	5 to 10 mg	5 mg
Fexofenadine	60 mg (IR); 180 mg (ER)	15 to 30 mg
Cetirizine	5 to 10 mg	2.5 to 5 mg
Decongestant
Phenylephrine	5 to 10 mg	2.5 mg
Pseudoephedrine	30 to 60 mg (IR); 120 to 240 mg (ER)	1 mg/kg up to 15 mg (IR)
Phenylpropanolamine^¶	25 mg (IR) to 50 mg (ER)	6.25 to 12.5 mg (IR)
Cough suppressant
Dextromethorphan	10 to 20 mg (IR); 60 mg (ER)	2.5 to 7.5 mg (IR); 15 mg (ER)
Antipyretic/analgesic
Acetaminophen (paracetamol)	325 to 1000 mg (IR); 1300 mg (ER)	10 to 15 mg/kg up to 650 mg
Ibuprofen	200 to 400 mg	4 to 10 mg/kg up to 300 mg (age ≥12 years: up to 400 mg)
Analgesic
Naprosyn	200 mg (base)	5 mg/kg up to 200 mg (base)
Ketoprofen^Δ	12.5 to 25 mg (IR); 100 to 200 mg (ER)	0.5 mg/kg up to 25 mg (IR)
Expectorant
Guaifenesin	200 to 400 mg (IR); 600 to 1200 mg (ER)	50 to 200 mg (IR)

IR: immediate release; ER: extended release.
* Over-the-counter (OTC) preparations may contain combinations of several active ingredients. If possible, the clinician should obtain the container with the listed ingredients rather than relying upon the reported brand name because different preparations can have similar or the same brand names. Doses reflect the recommended over-the-counter dose. Higher doses may be approved for patients under medical supervision.
¶ Not available in United States.
Δ Available OTC in many countries; requires a prescription in the United States.

Graphic 94240 Version 3.0

خرید پکیج

Common active ingredients of orally administered over-the-counter cough and cold preparations*