Magnesium transport in the distal convoluted tubule

Magnesium enters on the luminal side via the magnesium channel, transient receptor potential cation channel 6 (TRPM6), driven by the hyperpolarized membrane potential generated by the apical potassium channel, Kv1.1. Epidermal growth factor (EGF) stimulates trafficking of TRPM6 to the cell surface. The gamma subunit of the Na-K-ATPase participates in the pumping of sodium out of the cell, facilitated by basolateral potassium recycling by the potassium channel, Kir4.1/5.1. Basolateral magnesium exit may occur through cyclin M2 (CNNM2), which acts as a magnesium channel or transporter.