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Pentafluoropropane and tetrafluoroethane: Drug information

Pentafluoropropane and tetrafluoroethane: Drug information
(For additional information see "Pentafluoropropane and tetrafluoroethane: Patient drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Gebauer's Instant Ice [OTC];
  • Gebauer's Pain Ease;
  • Gebauer's Spray and Stretch
Pharmacologic Category
  • Anesthetic, Topical
Dosing: Adult
Myofascial pain, restricted motion, muscle tension

Myofascial pain, restricted motion, muscle tension: Topical: Spray skin over affected muscle (include muscle attachment over trigger point, through and over the reference zone) at a rate of ~4 inches/second (10 centimeter/second); passively stretch muscle during spray application; may repeat if necessary.

Temporary relief of minor sports injury, preinjection anesthesia, anesthetic in minor surgery and muscle spasms

Temporary relief of minor sports injury, preinjection anesthesia, anesthetic in minor surgery and muscle spasms: Topical: Dosage varies with duration of application; use smallest dose necessary. Spray over affected area for 4 to 10 seconds; spray until skin begins to turn white; do not frost the skin. Reapply as needed. When using for muscle spasm, gently stretch muscle immediately after application.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Older Adult

Refer to adult dosing.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Frequency not defined.

Dermatologic: Disorder of skin pigmentation, skin irritation

Contraindications

Hypersensitivity to pentafluoropropane, tetrafluoroethane, or any other component of the formulation

Warnings/Precautions

Concerns related to adverse effects:

• Skin irritation: Discontinue use if skin becomes irritated.

• Skin pigmentation: Overuse may alter skin pigmentation.

Disease-related concerns:

• Diabetes: Do not use in patients with diabetes mellitus.

• Poor circulation: Do not use in patients with poor circulation.

Other warnings/precautions:

• Appropriate use: For external use only; avoid use in eyes; do not use on large areas of damaged skin, puncture wounds, animal bites, serious wounds, or genital mucous membranes. Do not use in patients with insensitive skin. Provides temporary relief (<1 minute) in sports injuries; initiate other therapy as soon as possible. If used to produce local freezing, protect adjacent skin areas with petroleum.

• Self-medication (OTC use): When used for self-medication, do not spray near face, on open wounds, or abraded skin.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Aerosol, spray, topical:

Gebauer's Spray and Stretch: Pentafluoropropane 95% and tetrafluoroethane 5% (116 mL) [available in fine stream spray]

Gebauer's Pain Ease: Pentafluoropropane 95% and tetrafluoroethane 5% (30 mL, 116 mL) [available in mist spray or medium stream spray]

Gebauer's Instant Ice [OTC]: Pentafluoropropane 95% and tetrafluoroethane 5% (103.5 mL) [available in mist spray or stream spray]

Generic Equivalent Available: US

No

Administration: Adult

For external use only. Discontinue if skin becomes irritated. Avoid use in eyes. Do not use near face, open wounds, abraded skin, puncture wounds, animal bites, or genital mucous membranes. When used for local tissue freezing, adjacent skin areas should be protected with petroleum. Avoid use on unaffected areas. If the aerosol quits spraying, turn actuator button ~1/2 turn and spray again.

Myofascial pain: Hold can upright 12 to 18 inches (30 to 46 centimeters) away from treatment area. Aim the spray so it meets the skin at an acute angle. Direct in parallel sweeps 0.5 to 1 inch (1.5 to 2 centimeters) apart at the rate of 4 inches/second (10 centimeters/second). Passively stretch the muscle during application; increase the force of the stretch with successive sweeps. As the muscle relaxes, establish a new stretch length. For complete pain relief, the full, normal length of the muscle must be reached. Apply moist heat for 10 to 15 minutes after treatment.

Sports injuries (minor), preinjection anesthesia, topical anesthesia in minor surgery: Hold can upright 3 to 7 inches (8 to 18 centimeters) away from treatment area. Spray steadily for 4 to 10 seconds; perform procedure immediately. Anesthetic action lasts a few seconds to 1 minute.

Use: Labeled Indications

Pain relief: Management of myofascial pain, restricted motion, and muscle tension; temporary relief of muscle spasm and minor sports injuries (eg, bruises, contusions, cuts/abrasions, swelling, minor sprains, strains); control of pain associated with injections or minor surgical procedures

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Pregnancy Considerations

Animal reproduction studies have not been conducted.

Mechanism of Action

Vapocoolant (skin refrigerant) and counterirritant

Pharmacokinetics (Adult Data Unless Noted)

Duration of action: Anesthetic effect: Seconds to 1 minute

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (GB) United Kingdom: Dermogesic;
  • (PR) Puerto Rico: Gebauers pain ease | Pain ease
  1. Gebauer's Pain Ease (pentafluoropropane and tetrafluoroethane) [prescribing information]. Cleveland, OH: Gebauer Company.
  2. Gebauer's Spray and Stretch (pentafluoropropane and tetrafluoroethane) [prescribing information]. Cleveland, OH: Gebauer Company; October 2018.
Topic 9454 Version 66.0

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