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Tigecycline: Drug information

Tigecycline: Drug information
(For additional information see "Tigecycline: Patient drug information" and see "Tigecycline: Pediatric drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
ALERT: US Boxed Warning
Mortality:

An increase in all-cause mortality has been observed in a meta-analysis of phase 3 and 4 clinical trials in tigecycline-treated patients versus comparator. The cause of this mortality risk difference of 0.6% (95% confidence interval [CI], 0.1 to 1.2) has not been established. Tigecycline should be reserved for use in situations when alternative treatments are not suitable.

Brand Names: US
  • Tygacil
Brand Names: Canada
  • Tygacil
Pharmacologic Category
  • Antibiotic, Glycylcycline
Dosing: Adult

Note: Given the increased mortality risk associated with tigecycline, reserve for use in situations when alternative treatments are not suitable (Ref).

Acinetobacter baumannii infection, multidrug-resistant

Acinetobacter baumannii infection, multidrug-resistant (off-label use): IV: 200 mg once, then 100 mg every 12 hours (Ref). For mild infection, may use as monotherapy (alternative agent); for moderate to severe infection, administer as part of an appropriate combination regimen. Note: Not recommended for urinary tract infection or as monotherapy for bloodstream infections (Ref).

Intra-abdominal infection

Intra-abdominal infection (alternative agent):

Note: Not recommended for routine empiric use. Reserve use for patients with or at risk for certain multidrug-resistant organisms (eg, K. pneumoniae carbapenemase-producing Enterobacteriaceae, Acinetobacter baumannii) (Ref).

IV: 100 mg once, then 50 mg every 12 hours; some experts suggest 200 mg once, then 100 mg every 12 hours for complicated infection (ie, with abscess or involving the peritoneum) (Ref). Some experts use as part of an appropriate combination regimen for certain resistant organisms (Ref). Total duration of therapy (which may include transition to oral antibiotics) is 4 to 5 days following adequate source control (Ref).

Pneumonia, community-acquired

Pneumonia, community-acquired (alternative agent for patients unable to tolerate beta-lactams or fluoroquinolones): Inpatients without risk factors for Pseudomonas aeruginosa; not recommended for routine empiric use (Ref).

IV: 100 mg as a single dose, then 50 mg every 12 hours (Ref). Total duration (which may include oral step-down therapy) is a minimum of 5 days; patients should be clinically stable with normal vital signs before therapy is discontinued (Ref).

Skin/skin structure infection, complicated

Skin/skin structure infection, complicated: IV: Initial: 100 mg as a single dose; Maintenance dose: 50 mg every 12 hours for 5 to 14 days.

Stenotrophomonas maltophilia infection, multidrug-resistant

Stenotrophomonas maltophilia infection, multidrug-resistant (alternative agent) (off-label use): IV: 200 mg once, then 100 mg every 12 hours. For mild infection, may use as monotherapy; for moderate to severe infection, administer as part of an appropriate combination regimen. Note: Not recommended for urinary tract infection or as monotherapy for bloodstream infections (Ref).

Dosing: Kidney Impairment: Adult

The renal dosing recommendations are based upon the best available evidence and clinical expertise. Senior Editorial Team: Bruce Mueller, PharmD, FCCP, FASN, FNKF; Jason Roberts, PhD, BPharm (Hons), B App Sc, FSHP, FISAC; Michael Heung, MD, MS.

Altered kidney function: No dosage adjustment necessary for any degree of kidney dysfunction (Ref).

Hemodialysis, intermittent (thrice weekly): Poorly dialyzed: No supplemental dose or dosage adjustment necessary (Ref).

Peritoneal dialysis: Unlikely to be dialyzed: No dosage adjustment necessary (Ref).

CRRT: No dosage adjustment necessary (Ref).

PIRRT (eg, sustained, low-efficiency diafiltration): No dosage adjustment necessary (Ref).

Dosing: Hepatic Impairment: Adult

Mild-to-moderate hepatic impairment (Child-Pugh class A or B): No dosage adjustment necessary.

Severe hepatic impairment (Child-Pugh class C): Initial: 100 mg single dose; Maintenance: 25 mg every 12 hours.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Tigecycline: Pediatric drug information")

General dosing, bacterial infection: Limited data available: Note: Use should be reserved for situations when no effective alternative therapy is available and when benefits are expected to outweigh risks (Ref). Duration of therapy dependent on severity and site of infection and response to therapy.

Infants and Children <8 years: Reported dosing variable: Note: Use in in patients <8 years is not recommended due to adverse effects on tooth development and uncertain dosing; however, use has been described in scenarios where alternative options were unavailable (Ref).

IV: 1.5 to 2 mg/kg loading dose once, then 1 to 2 mg/kg/dose every 12 hours; maximum dose: 50 mg/dose (Ref). Note: Higher loading doses of up to 4 mg/kg/dose have also been reported to treat multidrug resistant gram-negative bacteria (Ref).

Children ≥8 years and Adolescents: IV: 1.5 to 2 mg/kg loading dose once, then 1.2 to 2 mg/kg/dose every 12 hours; usual maximum dose: 50 mg/dose (Ref). A higher dose (4 mg/kg loading dose [maximum dose: 200 mg/dose], followed by 2 to 3.2 mg/kg/dose [maximum dose: 100 mg/dose] every 12 hours) has been suggested to mimic high-dose therapy used in adults, particularly for infections caused by carbapenem-resistant Enterobacterales infections (Ref).

Mycobacterial infection, nontuberculous; pulmonary

Mycobacterial infection, nontuberculous; pulmonary: Limited data available: Note: Use as part of an appropriate combination regimen; typically treat ≥12 months after culture conversion (Ref).

Children 8 to <12 years: IV: 1.2 mg/kg/dose every 12 hours; maximum dose: 50 mg/dose (Ref).

Children ≥12 years and Adolescents: IV: 100 mg loading dose once, followed by 50 mg every 12 to 24 hours (Ref). Note: A reduced dosage regimen of 50 mg every 24 hours or 25 mg every 12 to 24 hours may be considered in patients who do not tolerate higher doses (Ref).

Dosing: Kidney Impairment: Pediatric

Altered kidney function: There are no pediatric-specific recommendations provided in the manufacturer's labeling; based on experience in adult patients, no dosage adjustment necessary.

Hemodialysis: Poorly dialyzed. There are no pediatric-specific recommendations provided in the manufacturer's labeling; based on experience in adult patients, no dosage adjustment necessary.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling. In adult patients with mild to moderate impairment (Child-Pugh class A or B), no dosage adjustment necessary; for severe hepatic impairment (Child Pugh class C), dosing adjustment is suggested.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

>10%: Gastrointestinal: Diarrhea (12%), nausea (24% to 35%), vomiting (16% to 20%)

1% to 10%:

Cardiovascular: Phlebitis (3%), septic shock, thrombophlebitis

Dermatologic: Pruritus, skin rash (3%)

Endocrine & metabolic: Hypocalcemia, hypoglycemia, hyponatremia (2%), increased amylase (3%)

Gastrointestinal: Abdominal pain (6%), abnormal stools, anorexia, dysgeusia, dyspepsia (2%)

Genitourinary: Leukorrhea, vaginitis, vulvovaginal candidiasis

Hematologic & oncologic: Anemia (5%), eosinophilia, hypoproteinemia (5%), increased INR, prolonged partial thromboplastin time, prolonged prothrombin time, thrombocytopenia

Hepatic: Hyperbilirubinemia (2%), increased serum alanine aminotransferase (5%), increased serum alkaline phosphatase (3%), increased serum aspartate aminotransferase (4%), jaundice

Hypersensitivity: Hypersensitivity reaction

Infection: Abscess (2%), infection (7%), sepsis

Local: Inflammation at injection site, injection site phlebitis, injection site reaction, pain at injection site, swelling at injection site

Nervous system: Chills, dizziness (3%), headache (6%)

Neuromuscular & skeletal: Asthenia (3%)

Renal: Increased blood urea nitrogen (3%), increased serum creatinine

Respiratory: Pneumonia (2%)

Postmarketing:

Dermatologic: Severe dermatological reaction, Stevens-Johnson syndrome

Gastrointestinal: Acute pancreatitis, Clostridioides difficile associated diarrhea, enamel hypoplasia

Hematologic & oncologic: Hemorrhage (including rectal bleeding and ecchymoses [Ciu 2019]), hypofibrinogenemia

Hepatic: Hepatic failure, intrahepatic cholestasis

Hypersensitivity: Anaphylaxis, nonimmune anaphylaxis

Contraindications

Hypersensitivity to tigecycline or any component of the formulation

Canadian labeling: Additional contraindications (not in US labeling): Hypersensitivity to tetracycline class of antibiotics

Warnings/Precautions

Concerns related to adverse effects:

• Anaphylactic/Hypersensitivity reactions: May cause life-threatening anaphylaxis. Due to structural similarity with tetracyclines, avoid use in patients with known hypersensitivity to tetracycline-class antibiotics.

• Antianabolic effects: May be associated with antianabolic effects observed with the tetracycline class (including increased BUN, azotemia, acidosis, and hyperphosphatemia).

• Coagulopathy: May be associated with abnormalities of blood coagulation parameters, including prolongation of PT and aPTT and decreased fibrinogen that may be dose- and/or time-dependent, in particular in patients with renal and hepatic impairment; discontinue use when suspected (Cui 2019).

• Hepatotoxicity: Abnormal liver function tests (increased total bilirubin, prothrombin time, transaminases) have been reported. Isolated cases of significant hepatic dysfunction and hepatic failure have occurred. Closely monitor for worsening hepatic function in patients who develop abnormal liver function tests during therapy. Adverse hepatic effects may occur after drug discontinuation.

• Pancreatitis: Acute pancreatitis (including fatalities) has been reported, including patients without known risk factors; discontinue use when suspected.

• Photosensitivity: May be associated with photosensitivity due to structural similarities with tetracyclines.

• Pseudotumor cerebri: May be associated with pseudotumor cerebri due to structural similarities with tetracyclines.

• Superinfection: Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed >2 months postantibiotic treatment.

• Treatment-related mortality: [US Boxed Warning]: In a meta analysis of Phase 3 and 4 clinical trials, an increase in all-cause mortality has been observed in tigecycline-treated patients versus comparator-treated patients. The cause of the mortality risk difference (0.6% [95% CI 0.1, 1.2]) has not been established. Use should be reserved for situations in which alternative treatments are not suitable. In general, deaths were the result of worsening infection, complications of infection, or underlying comorbidity.

Disease-related concerns:

• Hepatic impairment: Use with caution in patients with hepatic impairment; dosage adjustment recommended in severe hepatic impairment.

• Intra-abdominal infections: Avoid use as monotherapy for patients with intestinal perforation (in the small sample of available cases, sepsis/septic shock occurred more frequently than patients treated with imipenem/cilastatin comparator).

Special populations:

• Pediatric: Safety and efficacy in children and adolescents <18 years of age have not been established due to increased mortality observed in trials of adult patients. Use only if no alternative antibiotics are available. Because of potential effects on tooth development (yellow-gray-brown discoloration), use in patients <8 years of age is not recommended.

Other warnings/precautions:

• Appropriate use: Do not use for diabetic foot infections; non-inferiority was not demonstrated in studies. Do not use for healthcare-acquired pneumonia (HAP) or ventilator-associated pneumonia (VAP); increased mortality and decreased efficacy have been reported in HAP and VAP trials.

Warnings: Additional Pediatric Considerations

Tigecycline use in individuals <8 years of age may result in permanent tooth discoloration (yellow, gray, or brown) and/or enamel hypoplasia. Specific incidence of tooth discoloration following tigecycline treatment in patients <8 years is unknown; with tetracyclines in general, discoloration is more common with long-term use but may also be observed with repeated, short courses. While doxycycline courses up to 21 days have been considered acceptable and low-risk for discoloration, doxycyclines calcium-binding capacity is lower than that of tetracycline; tigecyclines calcium-binding capacity is not known (Red Book [AAP 2021]; Stultz 2019; Zhu 2021). Therefore, doxycycline use recommendations cannot be applied to tigecycline. In a dental evaluation of 12 patients who had previously received tigecycline while <8 years old, 2 patients (16.7%) developed mild tooth discoloration after receiving tigecycline for ≥19 days; definitive causation was not able to be assessed (Zhu 2021). In a retrospective chart review of 91 pediatric patients aged 7 months to 17.5 years who received tigecycline for a median of 12 days (range: 3 to 27 days), no tooth discoloration was documented during 2 years of follow-up for any patient; however, study methods limit conclusions (Aslan 2022). Tooth discoloration has been reported in a 9-year-old who received tigecycline for 47 days (Lin 2018).

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution Reconstituted, Intravenous [preservative free]:

Tygacil: 50 mg (1 ea) [contains lactose]

Generic: 50 mg (1 ea)

Generic Equivalent Available: US

Yes

Pricing: US

Solution (reconstituted) (Tigecycline Intravenous)

50 mg (per each): $124.80 - $187.20

Solution (reconstituted) (Tygacil Intravenous)

50 mg (per each): $120.00

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution Reconstituted, Intravenous:

Tygacil: 50 mg (1 ea) [contains lactose]

Generic: 50 mg (1 ea)

Administration: Adult

IV: Infuse over 30 to 60 minutes through dedicated line or via Y-site. If the same IV line is used for sequential infusion of several drugs, flush line with NS, D5W, or LR before and after tigecycline administration.

Administration: Pediatric

IV: Infuse over 30 to 60 minutes through dedicated line or via Y-site (Ref).

Use: Labeled Indications

Intra-abdominal infection: Treatment of complicated intra-abdominal infections in patients ≥18 years of age caused by Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Enterococcus faecalis (vancomycin-susceptible isolates), Staphylococcus aureus (methicillin-susceptible and methicillin-resistant isolates), Streptococcus anginosus group (includes S. anginosus, Streptococcus intermedius, and Streptococcus constellatus), Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Clostridium perfringens, and Peptostreptococcus micros.

Pneumonia, community acquired: Treatment of community-acquired bacterial pneumonia in patients ≥18 years of age caused by Streptococcus pneumoniae (penicillin-susceptible isolates), including cases with concurrent bacteremia, Haemophilus influenzae, and Legionella pneumophila.

Skin and skin structure infections, complicated: Treatment of complicated skin and skin structure infections in patients ≥18 years of age caused by E. coli, E. faecalis (vancomycin-susceptible isolates), S. aureus (methicillin-susceptible and methicillin-resistant isolates), Streptococcus agalactiae, S. anginosus group (includes S. anginosus, S. intermedius, and S. constellatus), Streptococcus pyogenes, E. cloacae, K. pneumoniae, and B. fragilis.

Limitations of use: Not indicated for treatment of diabetic foot infections; a clinical trial failed to demonstrate noninferiority of tigecycline for treatment of diabetic foot infections. Not indicated for treatment of hospital-acquired or ventilator-associated pneumonia; greater mortality and decreased efficacy were reported in tigecycline-treated patients in a comparative clinical trial.

Use: Off-Label: Adult

Acinetobacter baumannii infection, multidrug-resistant; Stenotrophomonas maltophilia infection

Metabolism/Transport Effects

None known.

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.

Aminolevulinic Acid (Systemic): Photosensitizing Agents may enhance the photosensitizing effect of Aminolevulinic Acid (Systemic). Risk X: Avoid combination

Aminolevulinic Acid (Topical): Photosensitizing Agents may enhance the photosensitizing effect of Aminolevulinic Acid (Topical). Risk C: Monitor therapy

Bacillus clausii: Antibiotics may diminish the therapeutic effect of Bacillus clausii. Management: Bacillus clausii should be taken in between antibiotic doses during concomitant therapy. Risk D: Consider therapy modification

BCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Risk X: Avoid combination

BCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Risk C: Monitor therapy

Cholera Vaccine: Antibiotics may diminish the therapeutic effect of Cholera Vaccine. Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics. Risk X: Avoid combination

Fecal Microbiota (Live) (Oral): May diminish the therapeutic effect of Antibiotics. Risk X: Avoid combination

Fecal Microbiota (Live) (Rectal): Antibiotics may diminish the therapeutic effect of Fecal Microbiota (Live) (Rectal). Risk X: Avoid combination

Immune Checkpoint Inhibitors (Anti-PD-1, -PD-L1, and -CTLA4 Therapies): Antibiotics may diminish the therapeutic effect of Immune Checkpoint Inhibitors (Anti-PD-1, -PD-L1, and -CTLA4 Therapies). Risk C: Monitor therapy

Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol. Risk C: Monitor therapy

Lithium: Tetracyclines may increase the serum concentration of Lithium. Risk C: Monitor therapy

Mecamylamine: Tetracyclines may enhance the neuromuscular-blocking effect of Mecamylamine. Risk X: Avoid combination

Methoxsalen (Systemic): Photosensitizing Agents may enhance the photosensitizing effect of Methoxsalen (Systemic). Risk C: Monitor therapy

Methoxyflurane: Tetracyclines may enhance the nephrotoxic effect of Methoxyflurane. Risk X: Avoid combination

Mipomersen: Tetracyclines may enhance the hepatotoxic effect of Mipomersen. Risk C: Monitor therapy

Neuromuscular-Blocking Agents: Tetracyclines may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. Risk C: Monitor therapy

Penicillins: Tetracyclines may diminish the therapeutic effect of Penicillins. Risk C: Monitor therapy

Porfimer: Photosensitizing Agents may enhance the photosensitizing effect of Porfimer. Risk C: Monitor therapy

Retinoic Acid Derivatives: Tetracyclines may enhance the adverse/toxic effect of Retinoic Acid Derivatives. The development of pseudotumor cerebri is of particular concern. Risk X: Avoid combination

Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Risk D: Consider therapy modification

Sulfonylureas: Tetracyclines may enhance the hypoglycemic effect of Sulfonylureas. Risk C: Monitor therapy

Tacrolimus (Systemic): Tigecycline may increase the serum concentration of Tacrolimus (Systemic). Risk C: Monitor therapy

Typhoid Vaccine: Antibiotics may diminish the therapeutic effect of Typhoid Vaccine. Only the live attenuated Ty21a strain is affected. Management: Avoid use of live attenuated typhoid vaccine (Ty21a) in patients being treated with systemic antibacterial agents. Postpone vaccination until 3 days after cessation of antibiotics and avoid starting antibiotics within 3 days of last vaccine dose. Risk D: Consider therapy modification

Verteporfin: Photosensitizing Agents may enhance the photosensitizing effect of Verteporfin. Risk C: Monitor therapy

Vitamin K Antagonists (eg, warfarin): Tetracyclines may enhance the anticoagulant effect of Vitamin K Antagonists. Risk C: Monitor therapy

Warfarin: Tigecycline may increase the serum concentration of Warfarin. Risk C: Monitor therapy

Pregnancy Considerations

Tigecycline crosses the placenta.

Tetracyclines accumulate in developing teeth and long tubular bones (Mylonas 2011). Permanent discoloration of teeth (yellow, gray, brown) can occur following in utero exposure and is more likely to occur following long-term use or short-term repeated exposure. In addition, tetracycline use has been associated with reversible retardation of skeletal development and reduced bone growth.

Breastfeeding Considerations

It is not known if tigecycline is found in breast milk.

According to the manufacturer, the decision to breastfeed during therapy should consider the risk of infant exposure, the benefits of breastfeeding to the infant, and the benefits of treatment to the mother. Although oral bioavailability is low and exposure to the breastfed infant is expected to be limited, the manufacturer does not recommend breastfeeding if maternal therapy is required for >3 weeks due to the potential risk of tooth discoloration and inhibition of bone growth in the infant. The manufacturer suggests temporarily pumping and discarding breast milk during therapy and for 9 days after the last maternal tigecycline dose to minimize exposure to the breastfed infant. In general, antibiotics that are present in breast milk may cause non-dose-related modification of bowel flora. Monitor infants for GI disturbances, such as thrush or diarrhea. Use of medications other than tetracyclines should be used when possible (WHO 2002).

Monitoring Parameters

Hepatic function (periodically); coagulation parameters (including aPTT, PTT, fibrinogen) at baseline and regularly during therapy. Observe for signs and symptoms of anaphylaxis during administration.

Mechanism of Action

A glycylcycline antibiotic that binds to the 30S ribosomal subunit of susceptible bacteria, thereby, inhibiting protein synthesis. Generally considered bacteriostatic; however, bactericidal activity has been demonstrated against isolates of S. pneumoniae and L. pneumophila. Tigecycline is a derivative of minocycline (9-t-butylglycylamido minocycline), and while not classified as a tetracycline, it may share some class-associated adverse effects. Tigecycline has demonstrated activity against a variety of gram-positive and -negative bacterial pathogens including methicillin-resistant staphylococci.

Pharmacokinetics (Adult Data Unless Noted)

Distribution: Vd: Children (8 to 11 years): 2.84 L/kg (range: 0.397 to 11.2 L/kg) (Purdy 2012); Adults: 7 to 9 L/kg; extensive tissue distribution; distributes into gallbladder, lung, and colon

Protein binding: 71% to 89%

Metabolism: Hepatic, via glucuronidation, N-acetylation, and epimerization to several metabolites, each <10% of the dose

Half-life elimination: Single dose: 27 hours; following multiple doses: 42 hours; increased by 23% in moderate hepatic impairment and 43% in severe hepatic impairment

Excretion: Feces (59%, primarily as unchanged drug); urine (33%, with 22% of the total dose as unchanged drug)

Clearance: Reduced by 25% in patient with moderate hepatic impairment and 55% in severe hepatic impairment.

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Tygacil;
  • (AR) Argentina: Tygacil;
  • (AT) Austria: Tigecyclin mylan | Tigecyclin sandoz;
  • (BD) Bangladesh: Tigacil | Widebac;
  • (BE) Belgium: Tigecyclin sandoz | Tigecycline accord | Tygacil;
  • (BG) Bulgaria: Tigecycline sandoz | Tygacil;
  • (BR) Brazil: Kalyme | Tigeciclina | Tygacil | Tyzel;
  • (CL) Chile: Tygacil;
  • (CO) Colombia: Expociclina | Geclix | Linicetil | Tigecic | Tigeciclina | Tigevitae | Tiglex | Tygacil;
  • (CZ) Czech Republic: Tigecycline mylan | Tigecycline olikla | Tigecycline sandoz | Tigecycline teva | Tygacil;
  • (DE) Germany: Tigecyclin hexal | Tigecyclin mylan | Tigecyclin ratiopharm;
  • (DO) Dominican Republic: Tygacil;
  • (EC) Ecuador: Tigeciclina;
  • (EE) Estonia: Tygacil;
  • (EG) Egypt: Tygacil;
  • (ES) Spain: Tigeciclina accord | Tigeciclina mylan | Tigeciclina normon;
  • (FI) Finland: Tygacil;
  • (FR) France: Tigecycline mylan | Tygacil;
  • (GB) United Kingdom: Tygacil;
  • (GR) Greece: Digazor | Tygacil;
  • (HK) Hong Kong: Tygacil;
  • (HU) Hungary: Tigecycline teva;
  • (IE) Ireland: Tygacil;
  • (IN) India: Algeline | Cachtin | Critig | Emtig | Het tg | Innocycline | Tigaphar | Tigebax | Tigecross | Tigene | Tigeniche | Tigeo | Tigerad | Tigercin | Tigeshan | Tigetuf | Tigi | Tigitrust | Tiziren | Tygacil | Tygaray | Zutig;
  • (IT) Italy: Tigeciclina | Tigeciclina mylan pharma;
  • (JO) Jordan: Tagix | Tygacil;
  • (JP) Japan: Tygacil;
  • (KE) Kenya: Tigebax | Tygacil | Tylin;
  • (KR) Korea, Republic of: Penmix tigecycline | Tygacil;
  • (KW) Kuwait: Tygacil;
  • (LB) Lebanon: Tagix | Tygacil;
  • (LT) Lithuania: Tygacil;
  • (LV) Latvia: Tygacil;
  • (MX) Mexico: Gecifhil | Grexyl | Linicetil | Treprex | Tygacil;
  • (MY) Malaysia: Tigar | Tygacil;
  • (NG) Nigeria: Tygacil;
  • (NL) Netherlands: Tygacil;
  • (NZ) New Zealand: Tigecycline juno | Tygacil;
  • (PE) Peru: Tigevitae | Tigilyn | Zomiprerin pd;
  • (PK) Pakistan: Tagagy | Tegecin | Tigacel | Tigasafe | Tigcil | Tigelin | Tigemark | Tigewel | Tigowin | Tilane | Tygacil | Tygin;
  • (PL) Poland: Tigecycline mylan | Tigecycline sandoz;
  • (PT) Portugal: Tigeciclina mylan | Tigeciclina tecnigen | Tigeciclina teva | Tygacil;
  • (PY) Paraguay: Spemicina | Tigeciclina cellofarm | Tigeciclina dasanti | Tigeciclina demotek | Tigeciclina imedic | Tygacil;
  • (QA) Qatar: Tygacil;
  • (RO) Romania: Tigeciclina atb | Tigeciclina mylan | Tygacil;
  • (RU) Russian Federation: Tigacil | Tigecycline j | Tigecycline psk;
  • (SA) Saudi Arabia: Tygacil;
  • (SE) Sweden: Tigecycline accord | Tigecycline mylan | Tygacil;
  • (SI) Slovenia: Tigeciklin sandoz | Tygacil;
  • (SK) Slovakia: Tigecycline sandoz | Tygacil;
  • (TH) Thailand: Bacticil | Capessa | Tyzel;
  • (TN) Tunisia: Tygacil;
  • (TR) Turkey: Mrsacin | Tigecid | Tigeject | Tigenex | Tigesil liyo | Tybicid | Tygepol | Tygex;
  • (TW) Taiwan: Tigelin | Tygacil;
  • (UA) Ukraine: Tigecycline vista;
  • (UY) Uruguay: Tygacil | Tygelina;
  • (ZA) South Africa: Rubicil | Tacyl | Tigebax | Tigecycline accord | Tygacil
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