Histologic features of proliferative nodules in giant congenital melanocytic nevi
At low magnification, the benign proliferative nodule (A, 40x; C, 100x) lacks the sharp demarcation seen in an atypical one (B, 40x; D, 100x). In addition, the benign proliferative nodule (E, 400x) does not possess the nuclear pleomorphism and mitotic figure seen in the atypical counterpart (F, 400x).
From: Phadke PA, Rakheja D, Le LP, et al. Proliferative nodules arising within congenital melanocytic nevi: a histologic, immunohistochemical, and molecular analyses of 43 cases. Am J Surg Pathol 2011; 35:656. DOI:
10.1097/PAS.0b013e31821375ea. Reproduced with permission from Lippincott Williams & Wilkins. Copyright © 2011 The Arthur Purdy Stout Society of Surgical Pathologists and The Gastrointestinal Pathology Society. Unauthorized reproduction of this material is prohibited.
