Deletions of the beta-globin cluster

Deletions of the β-globin cluster causing hereditary persistence of HbF (HPFH), ^Gγ(^Aγδβ)⁰ thalassemia, and ^Gγ^A(γδβ)⁰ thalassemia. Arrows in the cluster at the top of the diagram indicate DNase1 hypersensitive sites; those to the left of the ε gene define the lower LCR. The inverted region in the two double-deletion/inversion cases are shown as a dashed line.

* This deletion has only been found in trans to the HbS.

From: Thein SL, Wood WG. The molecular basis of β thalassemia, δβ thalassemia, and hereditary persistence of fetal hemoglobin. In: Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management, 2nd ed, Steinberg MH, Forget BG, Higgs DR, Weatherall DJ (Eds). Cambridge University Press, Cambridge 2009. p.323. Copyright © 2009 Cambridge University Press. Reprinted with permission.

Graphic 94662 Version 1.0

خرید پکیج

Deletions of the beta-globin cluster