Nailfold capillaroscopy in systemic sclerosis (scleroderma)

(A) Normal hairpin-shaped capillaries in a healthy subject. No relevant variation in the thickness of the capillary loops is evident.

Systemic sclerosis. Representative examples of architectural disorganization of the nailfold microvascular bed:

(B) Striking shape heterogeneity characterized by enlarged loops (*).
(C) Heterogeneity with tortuous capillaries, slightly dilated capillary loops (*), and capillary hemorrhages.
(D) Architectural derangement dominated by extremely enlarged loops (*) and neoformation of capillaries (arrow).
(E) Architectural disorganization characterized by irregular distribution of capillaries that shows a high degree of heterogeneity without loop enlargement.

Reproduced from: Walter G, Medico PD, Izzo F, Cervini C. Microvascular involvement in systemic sclerosis: capillaroscopic findings. Semin Arthritis Rheum 2001; 30:397. Illustration used with the permission of Elsevier Inc. All rights reserved.

Graphic 94667 Version 2.0

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Nailfold capillaroscopy in systemic sclerosis (scleroderma)