WHO categorization of tumors of the uterine corpus

Endometrial epithelial tumors and precursors

Precursors

Endometrial hyperplasia without atypia
Endometrial atypical hyperplasia/endometrioid intraepithelial neoplasia

Endometrial carcinomas

Endometrioid carcinoma
Serous carcinoma
Clear cell carcinoma
Undifferentiated carcinoma
Dedifferentiated carcinoma
Mixed carcinoma
Other endometrial carcinomas
Carcinosarcoma

Tumor-like lesions

Endometrial polyp
Endometrial metaplasia
Arias-Stella reaction

Mesenchymal tumors

Smooth muscle tumors

Leiomyoma
Intravenous leiomyomatosis
Smooth muscle tumor of uncertain malignant potential
Metastasizing leiomyoma
Leiomyosarcoma

Endometrial stromal and related tumors

Endometrial stromal nodule
Low-grade endometrial stromal sarcoma
High-grade endometrial stromal sarcoma
Undifferentiated uterine sarcoma

Miscellaneous mesenchymal tumors

Uterine tumor resembling ovarian sex cord tumor
Perivascular epithelioid cell tumor
Inflammatory myofibroblastic tumor
Other mesenchymal tumors

Mixed epithelial and mesenchymal tumors

Adenomyoma
Atypical polypoid adenomyoma
Adenosarcoma

Miscellaneous tumors

Central primitive neuroectodermal tumor/CNS embryonal tumor
Germ cell tumors

WHO: World Health Organization; CNS: central nervous system.

Reproduced with permission from: WHO Classification of Tumours Editorial Board. Female Genital Tumours [Internet]. Lyon (France): International Agency for Research on Cancer; 2020 [cited July 16, 2020]. (WHO classification of tumours series, 5th ed.; vol. 4). Available from: https://tumourclassification.iarc.who.int/.

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WHO categorization of tumors of the uterine corpus