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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Contraindications to fibrinolytic therapy for deep venous thrombosis or acute pulmonary embolism

Contraindications to fibrinolytic therapy for deep venous thrombosis or acute pulmonary embolism
Absolute contraindications
  • Prior intracranial hemorrhage
  • Known structural cerebral vascular lesion
  • Known malignant intracranial neoplasm
  • Ischemic stroke within 3 months (excluding stroke within 3 hours*)
  • Suspected aortic dissection
  • Active bleeding or bleeding diathesis (excluding menses)
  • Significant closed-head trauma or facial trauma within 3 months
Relative contraindications
  • History of chronic, severe, poorly controlled hypertension
  • Severe uncontrolled hypertension on presentation (SBP >180 mmHg or DBP >110 mmHg)
  • History of ischemic stroke >3 months prior
  • Traumatic or prolonged (>10 minutes) CPR or major surgery <3 weeks
  • Recent (within 2 to 4 weeks) internal bleeding
  • Noncompressible vascular punctures
  • Recent invasive procedure
  • For streptokinase/anistreplase – Prior exposure (>5 days ago) or prior allergic reaction to these agents
  • Pregnancy
  • Active peptic ulcer
  • Pericarditis or pericardial fluid
  • Current use of anticoagulant (eg, warfarin sodium) that has produced an elevated INR >1.7 or PT >15 seconds
  • Age >75 years
  • Diabetic retinopathy

SBP: systolic blood pressure; DBP: diastolic blood pressure; CPR: cardiopulmonary resuscitation; INR: international normalized ratio; PT: prothrombin time.

* The American College of Cardiology suggests that select patients with stroke may benefit from thrombolytic therapy within 4.5 hours of the onset of symptoms.
Reproduced with permission from the American College of Chest Physicians. Kearon C, Akl EA, Comerota AJ, et al. Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141:e419S. Copyright © 2012.
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