Serum autoantibodies in systemic sclerosis

Antigen	ANA staining pattern	Approximate frequency in all patients (%)	Clinical associations	Organ involvement
Scl-70 (topoisomerase-1)	Speckled	10 to 40	dcSSc	Lung fibrosis, isolated pulmonary hypertension less likely
Centromere	Centromere (kinetochore)	15 to 40	lcSSc	Pulmonary hypertension, esophageal disease, "protection" from lung fibrosis and renal disease
RNA polymerase III	Fine speckled nucleolar	4 to 25	dcSSc	Renal, skin, malignancy

Characteristics and clinical associations of the different autoantibodies that may be seen in scleroderma. dcSSc and lcSSc refer to diffuse and limited cutaneous systemic sclerosis, respectively.

ANA: antinuclear antibody; dcSSc: diffuse cutaneous systemic sclerosis; lcSSc: limited cutaneous systemic sclerosis.

Adapted from: Nihtyanova SI, Denton CP. Autoantibodies as predictive tools in systemic sclerosis. Nat Rev Rheumatol 2010; 6:112.

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Serum autoantibodies in systemic sclerosis