Levobupivacaine: International drug information (concise)

Dosage Range

Note: Dose ranges are not intended to guide prescribing; consult local prescribing information for additional dosage and administration information.

Children >6 months to <12 years: Surgical anesthesia: Local infiltration (Ilioinguinal/iliohypogastric block): 0.5 mL/kg/side of 0.25% solution (maximum: 1.25 mg/kg/side) or 0.25 mL/kg/side of 0.5% solution (maximum: 1.25 mg/kg/side).

Adults:

Surgical anesthesia:

Dental: 5 to 10 mL of 0.5% to 0.75% solution.

Epidural:

Cesarean section: 15 to 30 mL of 0.5% solution; maximum single dose: 150 mg.

Surgery, not cesarean section: 10 to 20 mL of 0.5% to 0.75% solution; maximum single dose: 150 mg; prolonged surgeries may require a maximum cumulative dose of 400 mg/24 hours.

Intrathecal: 3 mL of 0.5% solution.

Local infiltration: 1 to 60 mL of 0.25% solution; maximum: 150 mg.

Ophthalmic (peribulbar block): 5 to 15 mL of 0.75% solution.

Peripheral nerve: 1 to 40 mL of 0.25% solution or 1 to 30 mL of 0.5% solution; maximum: 150 mg.

Pain management:

Labor pain (epidural bolus): 6 to 20 mL of 0.25% solution.

Labor pain (epidural infusion): 10 to 15 mL/hour of 0.0625% solution or 4 to 10 mL/hour of 0.125% solution (maximum: 12.5 mg/hour; a maximum cumulative dose of 400 mg per 24 hours is recommended).

Peri- and postoperative pain (epidural infusion): 10 to 15 mL/hour of 0.0625% solution, or 10 to 15 mL/hour of 0.125% solution, or 5 to 7.5 mL/hour of 0.25% solution (maximum rate: 18.75 mg/hour; maximum cumulative dose: 400 mg/24 hours; however, postoperative doses up to 570 mg/24 hours have been well tolerated).