Prognostic subgroups | Cytogenetic abnormalities | Percent of patients | Survival (years, median) | AML evolution, 25 percent (years, median) | Hazard ratio OS | Hazard ratio AML |
Very good | –Y, del(11q) | 4 | 5.4 | NR | 0.7 | 0.4 |
Good | Normal, del(5q), del(12p), del(20q), double including del(5q) | 72 | 4.8 | 9.4 | 1 | 1 |
Intermediate | del(7q), +8, +19, i(17q), any other single or double independent clones | 13 | 2.7 | 2.5 | 1.5 | 1.8 |
Poor | –7, inv(3)/t(3q)/del(3q), double including –7/del(7q), complex: 3 abnormalities | 4 | 1.5 | 1.7 | 2.3 | 2.3 |
Very poor | Complex: >3 abnormalities | 7 | 0.7 | 0.7 | 3.8 | 3.6 |
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