Substances and medications with capacity to induce psychosis

Substance or medication	Examples
Alcohol and sedatives/hypnotics	Alcohol (intoxication or withdrawal), barbiturates, and benzodiazepines (particularly withdrawal)
Anabolic steroids	Testosterone, methyltestosterone
Analgesics	Meperidine, pentazocine, indomethacin
Anticholinergics	Atropine, scopolamine
Antidepressants	Bupropion, others if triggering a manic switch
Antiseizure medications	Zonisamide, other antiseizure medications at high doses
Antimalarial	Mefloquine, chloroquine
Antiparkinsonian	Levodopa, selegiline, amantadine, pramipexole, bromocriptine
Antivirals	Abacavir, efavirenz, nevirapine, acyclovir
Cannabinoids	Marijuana, synthetic cannabinoids (ie, "spice"), dronabinol
Cardiovascular	Digoxin, disopyramide, propafenone, quinidine
Corticosteroids	Prednisone, dexamethasone, etc
Hallucinogens	LSD (lysergic acid diethylamide), PCP (phencyclidine), ketamine, psilocybin-containing mushrooms, mescaline, synthetic "designer drugs" (eg, 2-CB, "N-Bomb" [25I-NBOMe]), salvia divinorum
Inhalants	Toluene, butane, gasoline
Interferons	Interferon alfa-2a/2b
Over-the-counter	Dextromethorphan, diphenhydramine, some decongestants
Stimulants	Cocaine, amphetamine/methamphetamine, methylphenidate, certain diet pills, "bath salts" (MDPV [methylenedioxypyrovalerone], mephedrone), MDMA (3,4-methylenedioxymethamphetamine)/ecstasy
Toxins	Carbon monoxide, organophosphates, heavy metals (eg, arsenic, manganese, mercury, thallium)

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