Hypophysitis associated with checkpoint inhibition

Sagittal MRI section from patient 7 before anti-CTLA-4 antibody treatment and after onset of clinical symptoms. Pituitary height is in parentheses.

MRI: magnetic resonance imaging.

Reproduced with permission from: Blansfield JA, Beck KE, Tran K, et al. Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. J Immunother 2005; 28:593. Copyright © 2005 Lippincott Williams & Wilkins. Unauthorized reproduction of this material is prohibited.

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Hypophysitis associated with checkpoint inhibition