Diagnostic and treatment algorithm for cofactor-responsive neonatal seizures

EEG: electroencephalography; IV: intravenous; PLP: pyridoxal 5'-phosphate; PNPO: pyridoxamine 5'-phosphate oxidase.

* Risk of apnea, particularly when pyridoxine is given IV.

¶ Repeated every 5 to 15 minutes up to a maximum of 500 mg with continuous EEG monitoring.

Δ Obtain genetics consultation if genetic analysis is nondiagnostic.

◊ Obtain genetics consultation if genetic analysis is nondiagnostic. If molecular genetic analysis unavailable, can confirm by significantly reduced sulfite oxidase enzyme activity in cultured fibroblasts.

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Diagnostic and treatment algorithm for cofactor-responsive neonatal seizures

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