Diagnostic and treatment algorithm for cofactor-responsive neonatal seizures

IV: intravenous; EEG: electroencephalography; PLP: pyridoxal 5'-phosphate; PNPO: pyridoxamine 5'-phosphate oxidase.

* Risk of apnea, particularly when pyridoxine is given IV.

¶ Repeated every 5 to 15 minutes up to a maximum of 500 mg with continuous EEG monitoring.

Δ Obtain genetics consultation if genetic analysis is nondiagnostic.