Outcomes of treatment for low-risk stage I gestational trophoblastic neoplasia at the New England Trophoblastic Center, 1965 to 2018

Stage I results
	Number of patients	Number of remissions
	664	664 (100 percent)
Initial therapy		557 (83.9 percent)
Sequential MTX/ActD		506
Combination chemotherapy*		7
Hysterectomy^¶		40
Second curettage		4
Resistant therapy		107 (16.1 percent)
Combination chemotherapy^Δ		81
Hysterectomy/local resection^¶		19
Other		7

MTX: methotrexate; ActD: actinomycin D; MAC: methotrexate, actinomycin D, cyclophosphamide; EMA: etoposide, methotrexate, actinomycin D; CO: cyclophosphamide plus vincristine.
* MAC.
¶ With adjunctive chemotherapy.
Δ MAC, EMA, EMA/CO.

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