Version July 2025
Tinea infection:
Tinea corporis/tinea cruris: Topical: Cream 1%, lotion 1%: Apply to affected and surrounding area(s) 1 to 2 times daily until clinical resolution, typically 1 to 3 weeks (Ref).
Tinea pedis (labeled use)/tinea manuum (off-label use): Topical: Cream 1%, lotion 1%: Apply to affected and surrounding area(s) 1 to 2 times daily until 1 week after clinical resolution, typically for 4 weeks total (Ref).
Tinea versicolor (pityriasis versicolor): Topical: Cream 1%: Apply to affected area(s) and immediate surrounding skin once daily for 2 weeks.
There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption.
There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption.
Refer to adult dosing.
(For additional information see "Oxiconazole: Pediatric drug information")
Tinea corporis (ringworm): Children and Adolescents: Topical: Cream 1%: Apply to affected and surrounding area(s) twice daily until clinical resolution; typically 2 weeks.
Tinea cruris (jock itch): Children and Adolescents: Topical: Cream 1%: Apply to affected and surrounding area(s) once daily until clinical resolution; typically 2 weeks.
Tinea pedis (athlete's foot): Children and Adolescents: Topical: Cream 1%: Apply to affected and surrounding area(s) once daily until clinical resolution; typically 4 weeks.
Tinea versicolor (pityriasis versicolor): Children and Adolescents: Topical: Cream 1%: Apply to affected and surrounding area(s) once daily for 2 weeks.
There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely necessary due to low systemic absorption.
There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely necessary due to low systemic absorption.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
1% to 10%: Dermatologic: Burning sensation of skin (≤1%), pruritus (≤2%)
<1%: Dermatologic: Allergic contact dermatitis, cutaneous nodule, desquamation, dyshidrotic eczema, erythema of skin, folliculitis, maceration of the skin, papule of skin, skin fissure, skin irritation, skin pain, skin rash, stinging of the skin, tingling of skin
Hypersensitivity to oxiconazole or any component of the formulation
Concerns related to adverse effects:
• Irritation: Discontinue if sensitivity or irritation occurs
Other warnings/precautions:
• Appropriate use: For topical use only; not for ophthalmologic, oral, or vaginal use.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Cream, External:
Oxistat: 1% (30 g [DSC], 60 g [DSC], 90 g [DSC]) [contains benzoic acid, cetyl alcohol, propylene glycol]
Generic: 1% (30 g, 60 g, 90 g)
Lotion, External:
Oxistat: 1% (30 mL, 60 mL) [contains benzoic acid, cetyl alcohol, propylene glycol]
May be product dependent
Cream (Oxiconazole Nitrate External)
1% (per gram): $10.40
Lotion (Oxistat External)
1% (per mL): $28.05
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
For external use only; avoid contact with eyes, nose, mouth, or other mucous membranes. Avoid occlusive dressings unless otherwise directed. Wash hands before and after use.
Topical: For external use only; avoid contact with eyes, nose, mouth, or other mucous membranes. Apply to the affected and immediate surrounding area(s). Avoid occlusive dressings unless otherwise directed. Wash hands before and after use.
Tinea infections:
Cream: Topical treatment of tinea pedis (athlete's foot); tinea cruris (jock itch); tinea corporis (ringworm) due to Trichophyton rubrum, Trichophyton mentagrophytes, or Epidermophyton floccosum; and tinea versicolor (pityriasis versicolor) due to Malassezia furfur
Lotion: Treatment of tinea pedis (athlete's foot); tinea cruris (jock itch); tinea corporis (ringworm) due to Trichophyton rubrum, Trichophyton mentagrophytes, or Epidermophyton floccosum
Tinea manuum
None known.
There are no known significant interactions.
When administered orally, teratogenic effects were not observed in animal reproduction studies.
Systemic absorption is low, however, the manufacturer reports that oxiconazole is excreted in breast milk.
The cytoplasmic membrane integrity of fungi is destroyed by oxiconazole which exerts a fungicidal activity through inhibition of ergosterol synthesis. Effective for treatment of tinea pedis, tinea cruris, tinea corporis, and tinea versicolor (pityriasis versicolor). Active against Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton violaceum, Microsporum canis, Microsporum audouinii, Microsporum gypseum, Epidermophyton floccosum, Candida albicans, and Malassezia furfur.
Absorption: In each layer of the dermis; very little systemically after one topical dose
Distribution: To each layer of the dermis
Excretion: Urine (<0.3%)
