Sensitivities for various immunohistochemical markers in differentiating hepatocellular carcinoma, cholangiocarcinoma, and metastatic adenocarcinoma

	HCC	CC	MA
Hep Par 1	86-96%	0-12.5%	0-14%
GPC3	75-88%	0-19%	0-6%
pCEA*	50-96%	100%	93-96%
MOC 31	0-14%	67-100%	66-100%
CK7	7-21%	78-100%	3-36%
CK8/18	70%	20%
CK19	0-10%	44-80%	29-64%
CK20	0-5%	10-11%	30-74%
CD34^¶	94-95%

IHC: immunohistochemical; adenoCA: adenocarcinoma; HCC: hepatocellular carcinoma; CC: cholangiocarcinoma; MA: metastatic adenocarcinoma; Hep Par 1: hepatocyte paraffin 1; GPC3: glypican-3; pCEA: polyclonal carcinoembryonic antigen; CK: cytokeratin.
* Positive pCEA staining is canalicular in HCC and membranous and/or cytoplasmic in CC and MA.
¶ Positive CD34 staining is a complete/diffuse staining pattern of the sinusoidal endothelial cells.

Original figure modified for this publication. Chan ES, Yeh MM. The use of immunohistochemistry in liver tumors. Clin Liver Dis 2010; 14:687. Table used with the permission of Elsevier Inc. All rights reserved.

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Sensitivities for various immunohistochemical markers in differentiating hepatocellular carcinoma, cholangiocarcinoma, and metastatic adenocarcinoma