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Targets of %fT>MIC for sub-classes of beta-lactams and gram-negative organisms

Targets of %fT>MIC for sub-classes of beta-lactams and gram-negative organisms
Bacteria-killing mechanism Penicillins (%) Cephalosporins (%) Carbapenems (%)
Bacteriostatic 30% 35-40% 20%
Bacteriocidal 50% 60-70% 40%
%fT>MIC: percentage of the dosing interval that the concentration of free drug remains about the minimum inhibitory concentration of the pathogen.
Data from: Lodise TP, Lomaestro BM, Drusano GL, Society of Infectious Diseases Pharmacists. Application of antimicrobial pharmacodynamic concepts into clinical practice: focus on beta-lactam antibiotics: insights from the Society of Infectious Diseases Pharmacists. Pharmacotherapy 2006; 26:1320 and Craig WA, Ebert S, and Wantabe Y. Differences in time above MIC required for efficacy of beta-lactams in animal infection models. Presented at the 33rd Interscience Conference on Animicrobial Agents and Chemotherapy, San Francisco CA, 1993, Abstract #86.
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