Pathologic and genetic features of hydatidiform mole

	Complete	Partial
Fetal or embryonic tissue	Absent	Present
Hydatidiform swelling of chorionic villi	Diffuse	Focal
Trophoblastic hyperplasia	Diffuse	Focal
Scalloping of chorionic villi	Absent	Present
Trophoblastic stromal inclusions	Absent	Present
Karyotype	46XX; 46XY; all chromosomes are paternal in origin	69XXY; 69XYY; 69XXX; extra set of chromosomes is paternal in origin
Immunochemistry*	p57-negative	p57-positive
Risk of gestational trophoblastic neoplasia	15 to 20%	1 to 5%

* p57 is expressed only on the maternal allele.

Adapted from: Berkowitz RS, Goldstein DP. The management of molar pregnancy and gestational trophoblastic tumors. In: Knapp RC, Berkowitz RS, eds. Gynecologic oncology. New York: MacMillan, 1993.

Graphic 97543 Version 3.0

خرید پکیج

Pathologic and genetic features of hydatidiform mole