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Poliovirus vaccine (inactivated) (IPV): Drug information

Poliovirus vaccine (inactivated) (IPV): Drug information
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Brand Names: US
  • IPOL
Brand Names: Canada
  • Imovax Polio
Pharmacologic Category
  • Vaccine;
  • Vaccine, Inactivated (Viral)
Dosing: Adult

Note: Consult CDC/ACIP annual immunization schedules or National Advisory Committee on Immunization (NACI) guidelines (Canada) for additional information including specific detailed recommendations for catch-up scenarios and/or care of patients with high-risk conditions. According to ACIP, doses administered ≤4 days before minimum interval or age are considered valid; however, local or state mandates may supersede this timeframe (Ref).

Primary immunization

Primary immunization (Ref):

IM, SUBQ: Administer 0.5 mL per dose for a total of 3 doses given as follows: Two 0.5 mL doses administered at a 1- to 2-month interval, followed by a third dose 6 to 12 months after the second dose. There is no need to restart the series if recommended intervals are exceeded.

Accelerated regimen:

If >8 weeks available prior to needed protection: 3 doses (0.5 mL/dose) administered ≥4 weeks apart.

If >4 but <8 weeks available prior to needed protection: 2 doses (0.5 mL/dose) administered ≥4 weeks apart then give remaining dose later at the recommended interval.

If <4 weeks available prior to needed protection: 1 dose (0.5 mL/dose) and then give remaining 2 doses later at the recommended intervals.

Incomplete vaccination: IM, SUBQ: Administer at least one 0.5 mL dose of IPV to complete the 3-dose series. Note: Complete adult vaccination is defined as receipt of ≥3 appropriately spaced doses of trivalent oral poliovirus vaccine (tOPV) or inactivated poliovirus vaccine (IPV) in any combination with the final dose administered on or after the fourth birthday.

Booster dose: IM, SUBQ: 0.5 mL as a single lifetime booster dose for fully vaccinated persons at increased risk of exposure.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Liver Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Poliovirus vaccine (inactivated) (IPV): Pediatric drug information")

Primary immunization

Primary immunization: Note: Use of the minimum age and minimum intervals (4 weeks) during the first 6 months of life should only be done when the vaccine recipient is at risk for imminent exposure to circulating poliovirus (shorter intervals and earlier start dates may lead to lower seroconversion) (Ref). Refer to CDC/ACIP for guidance on schedules and interval for individuals who received polio vaccination(s) (including oral formulation) outside of the United States (Ref).

Infants and Children 6 weeks to 47 months: IM, SUBQ: 0.5 mL per dose for a total of 3 doses administered as follows: 2 months, 4 months, and 6 to 18 months of age.

Booster immunization

Booster immunization:

Children 4 to 6 years: IM, SUBQ: 0.5 mL as a single dose administered at least 6 months after the previous dose.

Adolescents ≥18 years at increased risk of exposure to poliovirus: IM, SUBQ: 0.5 mL as a single dose (Ref).

Catch-up immunization

Catch-up immunization: Infants, Children, and Adolescents 4 months to 18 years: Note: Do not restart the series if doses have been given (OPV and/or IPV); refer to current immunization guidelines for specific schedule and timing of dose based on patient age and date and number of previous doses. IM, SUBQ: 0.5 mL per dose for a total of 1 to 4 doses.

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Liver Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Reported adverse reactions are for infants and children. Percentages noted with concomitant administration of DTP or DTaP vaccine and observed within 48 hours of injection, unless otherwise noted.

>10%:

Gastrointestinal: Anorexia (1% to 17%)

Local: Swelling at injection site (≤11%), tenderness at injection site (1% to 29%)

Nervous system: Fatigue (4% to 61%), irritability (7% to 65%)

1% to 10%:

Gastrointestinal: Vomiting (1% to 3%)

Local: Erythema at injection site (≤1%)

Nervous system: Excessive crying (1%; reported within 72 hours)

Miscellaneous: Fever (>39°C: ≤4%)

Postmarketing:

Cardiovascular: Syncope

Dermatologic: Skin rash, urticaria

Hematologic & oncologic: Lymphadenopathy

Hypersensitivity: Anaphylactic shock, anaphylaxis, hypersensitivity reaction, type 1 hypersensitivity reaction

Local: Rash at injection site, residual mass at injection site

Nervous system: Agitation, drowsiness, febrile seizure, headache, paresthesia, seizure

Neuromuscular & skeletal: Arthralgia, myalgia

Contraindications

Hypersensitivity to any component of the vaccine, including 2-phenoxyethanol, formaldehyde, neomycin, streptomycin and polymyxin B; anaphylaxis or anaphylactic shock occurring within 24 hours of administration of 1 dose of vaccine; acute, febrile illness (excluding minor illness with or without low-grade fever).

Note: Although the manufacturer’s labeling lists acute, febrile illness as a contraindication, the ACIP considers moderate or severe acute illness with or without fever to be a precaution to IPV vaccination (ACIP [Kroger 2023]).

Warnings/Precautions

Concerns related to adverse effects:

• Anaphylactoid/hypersensitivity reactions: Immediate treatment (including epinephrine 1 mg/mL) for anaphylactoid and/or hypersensitivity reactions should be available during vaccine use (ACIP [Kroger 2023]).

• Shoulder injury related to vaccine administration: Vaccine administration that is too high on the upper arm may cause shoulder injury (eg, shoulder bursitis, tendinopathy) resulting in shoulder pain and reduced range of motion following injection. Use proper injection technique for vaccines administered in the deltoid muscle (eg, injecting in the central, thickest part of the muscle) to reduce the risk of shoulder injury related to vaccine administration (Cross 2016; Foster 2013).

• Syncope: Syncope has been reported with use of injectable vaccines and may result in serious secondary injury (eg, skull fracture, cerebral hemorrhage); more often reported in adolescents and young adults and typically within 15 minutes after vaccination. Procedures should be in place to avoid injuries from falling and to restore cerebral perfusion if syncope occurs (ACIP [Kroger 2023]).

Disease-related concerns:

• Acute illness: The decision to administer or delay vaccination because of current or recent febrile illness depends on the severity of symptoms and the etiology of the disease. Postpone administration in patients with moderate or severe acute illness (with or without fever); vaccination should not be delayed for patients with mild acute illness (with or without fever) (ACIP [Kroger 2023]).

• Bleeding disorders: Use with caution in patients with bleeding disorders (including thrombocytopenia); bleeding/hematoma may occur from IM administration; if the patient receives antihemophilia or other similar therapy, IM injection can be scheduled shortly after such therapy is administered (ACIP [Kroger 2023]).

• History of polio infection: Patients with prior clinical poliomyelitis is not evidence of immunity; patients previously infected who are unvaccinated or with incomplete vaccination should be vaccinated.

Concurrent drug therapy issues:

• Anticoagulant therapy: Use with caution in patients receiving anticoagulant therapy; bleeding/hematoma may occur from IM administration (ACIP [Kroger 2023]).

• Immune globulin: Immune response may be decreased in patients receiving immune globulin.

• Vaccines: In order to maximize vaccination rates, the ACIP recommends simultaneous administration of all age-appropriate vaccines (live or non-live) for which a person is eligible at a single visit, unless contraindications exist. The use of combination vaccines is generally preferred over separate injections, taking into consideration provider assessment, patient preference, and adverse events. When using combination vaccines, the minimum age for administration is the oldest minimum age for any individual component; the minimum interval between dosing is the greatest minimum interval between any individual components. The ACIP prefers each dose of a specific vaccine in a series come from the same manufacturer when possible; however, vaccination should not be deferred because a specific product is unavailable (ACIP [Kroger 2023]).

Special populations:

• Altered immunocompetence: Postpone vaccination during periods of severe immunosuppression (eg, patients receiving chemo/radiation therapy or other immunosuppressive therapy [including high-dose corticosteroids]) if appropriate; may have a reduced response to vaccination. According to the manufacturer, patients with HIV infection, severe combined immunodeficiency, hypogammaglobulinemia, agammaglobulinemia, or altered immunity (due to corticosteroids, alkylating agents, antimetabolites, or radiation) may receive inactivated poliovirus vaccine (IPV). In general, household and close contacts of persons with altered immunocompetence may receive all age-appropriate vaccines. Non-live vaccines should be administered ≥2 weeks prior to planned immunosuppression when feasible; non-live vaccines administered during chemotherapy should be readministered after immune competence is regained (ACIP [Kroger 2023]; IDSA [Rubin 2014]).

• Pediatric: Use of the minimum age and minimum intervals during the first 6 months of life should only be done when the vaccine recipient is at risk for imminent exposure to circulating poliovirus (shorter intervals and earlier start dates may lead to lower seroconversion). Apnea has occurred following intramuscular vaccine administration in premature infants; consider clinical status implications. In general, preterm infants should be vaccinated at the same chronological age as full-term infants (ACIP [Kroger 2023]).

Dosage form specific issues:

• 2-phenoxyethanol: Products may contain 2-phenoxyethanol.

• Calf serum protein: Products may contain calf serum protein.

• Formaldehyde: Products may contain formaldehyde.

• Neomycin: Products may contain neomycin.

• Polymyxin B: Products may contain polymyxin B.

• Streptomycin: Products may contain streptomycin.

Other warnings/precautions:

• Antipyretics: Antipyretics have not been shown to prevent febrile seizures; antipyretics may be used to treat fever or discomfort following vaccination (ACIP [Kroger 2023]). One study reported that routine prophylactic administration of acetaminophen to prevent fever prior to vaccination decreased the immune response of some vaccines; the clinical significance of this reduction in immune response has not been established (Prymula 2009).

• Appropriate use: Specific recommendations for vaccination in immunocompromised patients with asplenia, cancer, HIV infection, cerebrospinal fluid leaks, cochlear implants, hematopoietic stem cell transplant (prior to or after), sickle cell disease, solid organ transplant (prior to or after), or those receiving immunosuppressive therapy for chronic conditions as well as contacts of immunocompromised patients are available from the IDSA (Rubin 2014).

• Effective immunity: Vaccination may not result in effective immunity in all patients. Response depends upon multiple factors (eg, age of patient) and may be improved by administering the vaccine at the recommended dose, route, and interval (ACIP [Kroger 2023]).

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Injection, suspension:

IPOL: Type 1 poliovirus 40 D-antigen units, type 2 poliovirus 8 D-antigen units, and type 3 poliovirus 32 D-antigen units per 0.5 mL (0.5 mL, 5 mL) [contains 2-phenoxyethanol, formaldehyde, calf serum protein, neomycin (may have trace amounts), streptomycin (may have trace amounts), and polymyxin B (may have trace amounts)]

Generic Equivalent Available: US

No

Administration: Adult

IM, SUBQ: Administer IM in the deltoid muscle or SUBQ in the upper outer triceps area; do not administer IV (Ref). Use proper injection technique for IM injection into the deltoid muscle (eg, injecting in the central, thickest part of the muscle) to reduce the risk of shoulder injury related to vaccine administration (Ref). Do not mix with other vaccines or injections; separate needles and syringes should be used for each injection. To prevent syncope related injuries, patients should be vaccinated while seated or lying down (Ref). US law requires that the date of administration, the vaccine manufacturer, lot number of vaccine, Vaccine Information Statement (VIS) edition date and date it was provided, and the administering person's name, title, and address be recorded. Imovax Polio (Canadian product) should be shaken well before use.

For patients at risk of hemorrhage following IM injection, the vaccine should be administered IM if, in the opinion of the physician familiar with the patient's bleeding risk, the vaccine can be administered by this route with reasonable safety. If the patient receives antihemophilia or other similar therapy, IM vaccination can be scheduled shortly after such therapy is administered. A fine needle (23-gauge or smaller) should be used for the vaccination and firm pressure on the site (without rubbing) for at least 2 minutes. The patient should be instructed concerning the risk of hematoma from the injection. Patients on anticoagulant therapy should be considered to have the same bleeding risks and treated as those with clotting factor disorders (Ref).

Administration: Pediatric

IM, SUBQ: Administer IM or SUBQ into midlateral aspect of the thigh in infants and small children; administer in the deltoid area in older children and adolescents; not for IV administration. Do not mix with other vaccines or injections; separate needles and syringes should be used for each injection (Ref). To prevent syncope-related injuries, adolescents should be vaccinated while seated or lying down (Ref). US law requires that the date of administration, the vaccine manufacturer, lot number of vaccine, Vaccine Information Statement (VIS) edition date and date it was provided, and the administering person's name, title, and address be recorded.

For patients at risk of hemorrhage following IM injection, the vaccine should be administered IM if, in the opinion of the physician familiar with the patient's bleeding risk, the vaccine can be administered by this route with reasonable safety. If the patient receives antihemophilia or other similar therapy, IM vaccination can be scheduled shortly after such therapy is administered. A fine needle (23 gauge or smaller) should be used for the vaccination and firm pressure applied to the site (without rubbing) for at least 2 minutes. The patient should be instructed concerning the risk of hematoma from the injection. Patients on anticoagulant therapy should be considered to have the same bleeding risks and treated as those with clotting factor disorders (Ref).

Medication Guide and/or Vaccine Information Statement (VIS)

In the U.S, the appropriate CDC-approved Vaccine Information Statement (VIS) must be provided to the patient prior to administering each dose of this vaccine; VIS is available at https://www.cdc.gov/vaccines/hcp/current-vis/polio.html.

Use: Labeled Indications

Poliovirus prevention:

Active immunization for prevention of poliomyelitis caused by poliovirus types 1, 2, and 3 in the following persons:

US labeling: Infants (≥6 weeks), children, adolescents, and adults

Canadian labeling: Infants (≥2 months), children, adolescents, and adults

The Advisory Committee on Immunization Practices (ACIP) and Canada's National Advisory Committee on Immunization (NACI) recommend vaccination for the following:

• All infants and children (CDC/ACIP 2009; PHAC 2015)

• Adults ≥18 years of age who are known or suspected to be unvaccinated or incompletely vaccinated against poliovirus. Note: Complete vaccination is defined as receipt of ≥3 appropriately spaced doses of trivalent oral poliovirus vaccine (tOPV) or inactivated poliovirus vaccine (IPV) in any combination with the final dose administered on or after the fourth birthday (CDC/ACIP [Kidd 2023]).

• Adults ≥18 years of age who are fully vaccinated and at increased risk for exposure, including (CDC/ACIP [Kidd 2023]):

- Travelers to regions or countries where poliomyelitis is endemic or epidemic.

- Health care workers or caregivers in close contact with patients in a community with a poliovirus outbreak.

- Laboratory and health care workers handling specimens that may contain polioviruses.

- Members of communities or specific population groups identified by public health authorities as being at increased risk for exposure to poliovirus due to an outbreak.

Medication Safety Issues
Sound-alike/look-alike issues:

IPV (inactivated poliovirus vaccine) may be confused with HPV (human papilloma virus vaccine)

IPV (inactivated poliovirus vaccine) may be confused with PPD (purified protein derivative tuberculin test).

IPV (inactivated poliovirus vaccine), a trivalent product, may be confused with OPV (oral poliovirus vaccine [live/bivalent]), which is no longer licensed in the United States, but still used in some other countries.

Administration issues:

Poliovirus vaccine (inactivated) may be confused with tuberculin products. Medication errors have occurred when poliovirus vaccine (IPV) has been inadvertently administered instead of tuberculin skin tests (PPD). Both of these products are refrigerated and often stored in close proximity to each other.

Metabolism/Transport Effects

None known.

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.

Acetaminophen: May decrease therapeutic effects of Vaccines. Management: Consider avoiding routine prophylactic use of acetaminophen before or during vaccine administration when possible. Acetaminophen is still recommended to treat fevers and/or pain that occurs after vaccination. Risk D: Consider Therapy Modification

Anti-CD20 B-Cell Depleting Therapies: May decrease therapeutic effects of Vaccines (Non-Live/Inactivated/Non-Replicating). Management: Give non-live/inactivated/non-replicating vaccines at least 2 weeks prior to initiation or 6 months after anti-CD20 B-cell depleting therapies. If vaccinated prior to B cell recovery, consider assessing immune response to vaccination. Risk D: Consider Therapy Modification

Atidarsagene Autotemcel: May increase adverse/toxic effects of Vaccines. Atidarsagene Autotemcel may decrease therapeutic effects of Vaccines. Risk X: Avoid

Cladribine: May decrease therapeutic effects of Vaccines (Non-Live/Inactivated/Non-Replicating). Management: Give non-live/inactivated/non-replicating vaccines at least 2 weeks prior to starting cladribine when possible. Patients vaccinated less than 14 days before initiating or during cladribine should be revaccinated at least 3 months after therapy is complete Risk D: Consider Therapy Modification

Corticosteroids (Systemic): May decrease therapeutic effects of Vaccines (Non-Live/Inactivated/Non-Replicating). Management: Administer vaccines at least 2 weeks prior to immunosuppressive corticosteroids if possible. If patients are vaccinated less than 14 days prior to or during such therapy, repeat vaccination at least 3 months after therapy if immunocompetence restored. Risk D: Consider Therapy Modification

Dinutuximab Beta: May decrease therapeutic effects of Vaccines (Non-Live/Inactivated/Non-Replicating). Risk X: Avoid

Elivaldogene Autotemcel: May increase adverse/toxic effects of Vaccines. Specifically, there may be a greater risk for contracting an infection from any live vaccine. Elivaldogene Autotemcel may decrease therapeutic effects of Vaccines. Management: Administration of vaccines is not recommended in the 6 weeks before myeloablative conditioning, and until hematologic recovery after elivaldogene autotemcel treatment. Risk X: Avoid

Fingolimod: May decrease therapeutic effects of Vaccines (Non-Live/Inactivated/Non-Replicating). Management: Vaccine efficacy may be reduced. Complete all age-appropriate vaccinations at least 2 weeks prior to starting fingolimod. If vaccinated during fingolimod therapy, revaccinate 2 to 3 months after fingolimod discontinuation. Risk D: Consider Therapy Modification

Immunosuppressants (Cytotoxic Chemotherapy): May decrease therapeutic effects of Vaccines (Non-Live/Inactivated/Non-Replicating). Management: Give non-live/inactivated/non-replicating vaccines at least 2 weeks prior to starting chemotherapy when possible. Patients vaccinated less than 14 days before or during chemotherapy should be revaccinated at least 3 months after therapy is complete. Risk D: Consider Therapy Modification

Immunosuppressants (Miscellaneous Oncologic Agents): May decrease therapeutic effects of Vaccines (Non-Live/Inactivated/Non-Replicating). Management: Give non-live/inactivated/non-replicating vaccines at least 2 weeks prior to initiation of immunosuppressants when possible. Patients vaccinated less than 14 days before or during therapy should be revaccinated at least 3 months after therapy is complete. Risk D: Consider Therapy Modification

Immunosuppressants (Therapeutic Immunosuppressant Agents): May decrease therapeutic effects of Vaccines (Non-Live/Inactivated/Non-Replicating). Management: Give non-live/inactivated/non-replicating vaccines at least 2 weeks prior to starting immunosuppressants when possible. Patients vaccinated less than 14 days before or during therapy should be revaccinated at least 2 to 3 months after therapy is complete. Risk D: Consider Therapy Modification

Methotrexate: May decrease therapeutic effects of Vaccines (Non-Live/Inactivated/Non-Replicating). Management: Administer vaccines at least 2 weeks prior to methotrexate initiation, if possible. If patients are vaccinated less than 14 days prior to or during methotrexate therapy, repeat vaccination at least 3 months after therapy if immunocompetence restored. Risk D: Consider Therapy Modification

Propacetamol: May decrease therapeutic effects of Vaccines. Management: Consider avoiding routine prophylactic use of propacetamol before or during vaccine administration when possible. Propacetamol is still recommended to treat fevers and/or pain that occurs after vaccination. Risk D: Consider Therapy Modification

Siponimod: May decrease therapeutic effects of Vaccines (Non-Live/Inactivated/Non-Replicating). Management: Avoid administration of non-live/inactivated/non-replicating vaccines during treatment with siponimod and for 1 month after discontinuation due to potential decreased vaccine efficacy. Risk D: Consider Therapy Modification

Teplizumab: May decrease therapeutic effects of Vaccines (Non-Live/Inactivated/Non-Replicating). Management: Vaccination with non-live/inactivated/non-replicating vaccines is not recommended in the 2 weeks prior to teplizumab therapy, during treatment, or for 6 weeks following completion of therapy. Risk D: Consider Therapy Modification

Pregnancy Considerations

Animal reproduction studies have not been conducted with the inactivated poliovirus vaccine (IPV).

The CDC considers pregnancy a precaution for IPV vaccination. Although vaccination of pregnant patients should be avoided on theoretical grounds, previously unvaccinated pregnant patients at increased risk for infection may be administered IPV; this includes pregnant patients who are traveling to countries where polio is epidemic or endemic, those in communities with disease caused by wild polioviruses, laboratory workers handling poliovirus specimens, health care personnel in close contact with infected patients, and unvaccinated persons whose children may be receiving an oral poliovirus vaccine (ACIP [Kroger 2023]; CDC/ACIP [Kidd 2023]).

Breastfeeding Considerations

It is not known if the components of this vaccine are present in breast milk.

Nonlive vaccines have not been shown to affect the safety of the breastfed infant or mother. Breastfeeding infants should be vaccinated according to the recommended schedules (ACIP [Kroger 2023]).

Monitoring Parameters

Monitor for hypersensitivity and syncope for 15 minutes following administration (ACIP [Kroger 2023]). If seizure-like activity associated with syncope occurs, maintain patient in supine or Trendelenburg position to reestablish adequate cerebral perfusion.

Mechanism of Action

As an inactivated virus vaccine, poliovirus vaccine induces active immunity against poliovirus types 1, 2, and 3 infection and provides protection from developing paralytic poliomyelitis.

Pharmacokinetics (Adult Data Unless Noted)

Onset of action: In the United States, ≥95% of infants and children 2 to 18 months of age who received 2 doses of the vaccine developed seroconversion to all 3 serotypes. A full 3-dose primary regimen is needed for optimal immunity. In children ≥2 years of age, 95% achieved seroconversion at 1 month following the third IPV dose (CDC/ACIP [Kidd 2023]).

Duration: Immunity typically persists for decades or possibly lifelong after a 3-dose primary series (WHO 2022).

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Poliorix;
  • (AR) Argentina: Imovax polio;
  • (BE) Belgium: Imovax polio;
  • (CH) Switzerland: Poliorix;
  • (CL) Chile: Poliorix;
  • (CN) China: Inactivated poliomyelitis vaccine made from sabin strains (vero cell) | Poliomyelitis vaccine (vero cell), inactivated, sabin strains;
  • (CZ) Czech Republic: IPV Virelon;
  • (DO) Dominican Republic: Imovax polio;
  • (FI) Finland: Poliorix;
  • (GR) Greece: Poliorix;
  • (JP) Japan: Imovax polio;
  • (KE) Kenya: Polprotec;
  • (KR) Korea, Republic of: Poliorix;
  • (KW) Kuwait: Poliorix;
  • (LU) Luxembourg: Imovax polio;
  • (LV) Latvia: Poliorix;
  • (PE) Peru: Polprotec;
  • (PH) Philippines: Poliorix;
  • (PL) Poland: Poliorix;
  • (PR) Puerto Rico: Ipol;
  • (QA) Qatar: Imovax Polio;
  • (RU) Russian Federation: Poliorix;
  • (TH) Thailand: Polprotec;
  • (ZA) South Africa: Imovax polio
  1. Centers for Disease Control and Prevention (CDC), “Imported Vaccine-Associated Paralytic Poliomyelitis -- United States,” MMWR Morb Mortal Wkly Rep, 2005, 55(4):97-9. [PubMed 16456525]
  2. Centers for Disease Control and Prevention (CDC). Updated recommendations of the Advisory Committee on Immunization Practices (ACIP) regarding routine poliovirus vaccination. MMWR Morb Mortal Wkly Rep. 2009;58(30):829-830. [PubMed 19661857]
  3. Cross GB, Moghaddas J, Buttery J, Ayoub S, Korman TM. Don't aim too high: avoiding shoulder injury related to vaccine administration. Aust Fam Physician. 2016;45(5):303‐306. [PubMed 27166466]
  4. Foster SL, Davis MV. Vaccine administration: preventing serious shoulder injuries. J Am Pharm Assoc (2003). 2013;53(1):102‐103. doi:10.1331/JAPhA.2013.13503 [PubMed 23636163]
  5. Imovax Polio (inactivated poliomyelitis vaccine) [product monograph]. Toronto, Ontario, Canada: Sanofi Pasteur Limited; October 2023.
  6. IPOL (poliovirus vaccine inactivated) [prescribing information]. Swiftwater, PA: Sanofi Pasteur Inc; May 2022.
  7. Kidd S, Clark T, Routh J, Cineas S, Bahta L, Brooks O. Use of inactivated polio vaccine among U.S. adults: updated recommendations of the Advisory Committee on Immunization Practices — United States, 2023. MMWR Morb Mortal Wkly Rep. 2023;72:1327-1330. doi: 10.15585/mmwr.mm7249a3 [PubMed 38060431]
  8. Kroger A, Bahta L, Hunter P. General best practice guidelines for immunization: best practices guidance of the Advisory Committee on Immunization Practices (ACIP). https://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/downloads/general-recs.pdf. Accessed April 30, 2021.
  9. Kroger A, Bahta L, Long S, Sanchez P. General best practice guidelines for immunization. Best practices guidance of the Advisory Committee on Immunization Practices (ACIP). https://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/downloads/general-recs.pdf. Updated 2023. Accessed April 20, 2023.
  10. Marin M, Patel M, Oberste S, Pallansch MA. Guidance for assessment of poliovirus vaccination status and vaccination of children who have received poliovirus vaccine outside the United States. MMWR Morb Mortal Wkly Rep. 2017;66(1):23-25. [PubMed 28081056]
  11. Prevots DR, Burr RK, Sutter RW, Murphy TV; Advisory Committee on Immunization Practices. Poliomyelitis prevention in the United States. Updated recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2000;49(RR-5):1-22. [PubMed 15580728]
  12. Prymula R, Siegrist CA, Chlibek R, et al, “Effect of Prophylactic Paracetamol Administration at Time of Vaccination on Febrile Reactions and Antibody Responses in Children: Two Open-Label, Randomised Controlled Trials,” Lancet, 2009, 374(9698):1339-50. [PubMed 19837254]
  13. Public Health Agency of Canada (PHAC). Poliomyelitis vaccines: Canadian immunization guide. https://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunization-guide-part-4-active-vaccines/page-17-poliomyelitis-vaccine.html. Updated January 2015. Accessed January 2023.
  14. Rubin LG, Levin MJ, Ljungman P, et al. 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host. Clin Infect Dis. 2014;58(3):e44-e100. [PubMed 24311479]
  15. Veiby G, Daltveit AK, Gilhus NE. Pregnancy, delivery and perinatal outcome in female survivors of polio. J Neurol Sci. 2007;258(1-2):27-32. doi:10.1016/j.jns.2007.02.019 [PubMed 17395208]
  16. Wodi AP, Murthy N, McNally V, Cineas S, Ault K. Advisory Committee on Immunization Practices recommended immunization schedule for children and adolescents aged 18 years or younger - United States, 2023. MMWR Morb Mortal Wkly Rep. 2023;72(6):137-140. doi:10.15585/mmwr.mm7206a1 [PubMed 36757872]
  17. World Health Organization (WHO). Guiding principles for immunization activities during the COVID-19 pandemic: interim guidance, 26 March 2020. Published March 26, 2020. Available at https://apps.who.int/iris/handle/10665/331590
  18. World Health Organization (WHO). Polio vaccines: WHO position paper - June 2022. Weekly Epidemiological Record. 2022;97(25):277-300. Available at https://www.who.int/publications/i/item/WHO-WER9725-277-300
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