PFO prevalence, attributable fraction, and estimated two-year risk of stroke/TIA

RoPE score	Cryptogenic stroke (n = 3023)			CS patients with PFO (n = 1324)
RoPE score	Number of patients	Prevalence of patients with a PFO, percent (95% CI)*	PFO-attributable fraction, percent (95% CI)*	Number of CS patients with PFO*	Estimated two-year stroke/TIA recurrence rate (Kaplan-Meier), percent (95% CI)
0 to 3	613	23 (19 to 26)	0 (0 to 4)	108	20 (12 to 28)
4	511	35 (31 to 39)	38 (25 to 48)	148	12 (6 to 18)
5	516	34 (30 to 38)	34 (21 to 45)	186	7 (3 to 11)
6	482	47 (42 to 51)	62 (54 to 68)	236	8 (4 to 12)
7	434	54 (49 to 59)	72 (66 to 76)	263	6 (2 to 10)
8	287	67 (62 to 73)	84 (79 to 87)	233	6 (2 to 10)
9 to 10	180	73 (66 to 79)	88 (83 to 91)	150	2 (0 to 4)

CI: confidence interval; CS: cryptogenic stroke; PFO: patent foramen ovale; RoPE: Risk of Paradoxical Embolism; TIA: transient ischemic attack.
* NOTE: 95% CI for PFO prevalence and attributable fraction based on normal approximation to the binomial distribution.

From: Kent DM, Ruthazer R, Weimar C, et al. An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke. Neurology 2013; 81:619. DOI: 10.1212/WNL.0b013e3182a08d59. Reproduced with permission from Lippincott Williams & Wilkins. Copyright © 2013 American Academy of Neurology. Unauthorized reproduction of this material is prohibited.

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PFO prevalence, attributable fraction, and estimated two-year risk of stroke/TIA