Version May 2024
| A. Periportal or periseptal interface hepatitis (piecemeal necrosis) | Score |
| Absent | 0 |
| Mild (focal, few portal areas) | 1 |
| Mild/moderate (focal, most portal areas) | 2 |
| Moderate (continuous around <50% of tracts or septa) | 3 |
| Severe (continuous around >50% tracts or septa) | 4 |
| B. Confluent necrosis | |
| Absent | 0 |
| Focal confluent necrosis | 1 |
| Zone 3 necrosis in some areas | 2 |
| Zone 3 necrosis in most areas | 3 |
| Zone 3 necrosis + occasional portal-central bridging | 4 |
| Zone 3 necrosis + multiple portal-central bridging | 5 |
| Panacinar or multiacinar necrosis | 6 |
| C. Focal (spotty) lytic necrosis, apoptosis, and focal inflammation | |
| Absent | 0 |
| One focus or less per 10X objective | 1 |
| Two to four foci per 10X objective | 2 |
| 5 to 10 foci per 10X objective | 3 |
| More than 10 foci per 10X objective | 4 |
| D. Portal inflammation | |
| None | 0 |
| Mild, some or all portal areas | 1 |
| Moderate, some or all portal areas | 2 |
| Moderate/marked, all portal areas | 3 |
| Marked, all portal areas | 4 |
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