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Diagnostic criteria for Kleine-Levin syndrome (ICSD-3-TR)

Diagnostic criteria for Kleine-Levin syndrome (ICSD-3-TR)
Criteria A through E must be met:
A The patient experiences at least two recurrent episodes of excessive sleepiness and sleep duration, each persisting for two days to five weeks.
B Episodes recur usually more than once a year and at least once every 18 months.
C The patient has normal or near-normal sleep and wakefulness, cognition, behavior, and mood between episodes, at least during the first years of the syndrome.
D The patient must demonstrate at least one of the following during episodes:
  1. Cognitive dysfunction
  2. Derealization
  3. Major apathy
  4. Disinhibited behavior (such as hypersexuality or hyperphagia)
E The symptoms and signs are not better explained by chronic insufficient sleep, a circadian rhythm sleep-wake disorder or other current sleep disorder, medical disorder, mental disorder, or medication/substance use or withdrawal.
Reproduced with permission from: International Classification of Sleep Disorders, 3rd ed, text revision (ICSD-3-TR), American Academy of Sleep Medicine 2023. Copyright © 2023 American Academy of Sleep Medicine.
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