Histologic features of mixed tumor of the skin (chondroid syringoma)

Cutaneous mixed tumors have an epithelial and stromal component. The stromal component typically has areas with abundant mucin and can have a chondroid appearance as depicted in this case. Mixed tumors can show apocrine or eccrine differentiation, and they frequently have a prominent myoepithelial component. The epithelial component in this example is minimal, but can be confirmed with a keratin stain (H&E 100x).