Version May 2024
Ophthalmic procedures:
Short corneal and conjunctival surgical procedures requiring deep ophthalmic anesthesia: Ophthalmic: Instill 1 drop in each eye every 5 to 10 minutes for 5 to 7 doses.
Tonometry, gonioscopy, foreign body or suture removal: Ophthalmic: Instill 1 to 2 drops in each eye just prior to procedure.
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
Refer to adult dosing.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
Frequency not defined.
1% to 10%: Ophthalmic: Burning sensation of eyes, stinging of eyes
<1%, postmarketing, and/or case reports: Allergic contact dermatitis, corneal opacity, epithelial keratopathy (sloughing of necrotic epithelium), eye irritation, hemophthalmos, hypersensitivity reaction, iritis, keratitis, ocular hyperemia
Hypersensitivity to proparacaine, fluorescein, or any component of the formulation
Disease-related concerns:
• Cardiovascular disease: Use with caution in patients with cardiovascular disease.
• Hyperthyroidism: Use with caution in patients with hyperthyroidism.
Concerns related to adverse effects:
• CNS stimulation/depression: Rarely, CNS stimulation followed by depression may occur following topical application of local anesthetics.
Other warnings/precautions:
• Appropriate use: For topical ophthalmic use only. To avoid contamination, do not touch dropper tip to eyelids or other surfaces. The anesthetized eye should be protected from irritation, foreign bodies, and rubbing to prevent inadvertent damage; use of an eye patch is recommended.
• Prolonged use: Delayed wound healing and/or permanent corneal opacification with vision loss may occur with prolonged use; not recommended.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Solution, ophthalmic:
Flucaine: Proparacaine hydrochloride 0.5% and fluorescein sodium 0.25% (5 mL)
Generic: Proparacaine hydrochloride 0.5% and fluorescein sodium 0.25% (5 mL)
Yes
Solution (Flucaine Ophthalmic)
0.25-0.5% (per mL): $1.83
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
For topical ophthalmic use only; avoid touching tip of dropper to eye, fingers, or other surfaces. Protect eye from irritation, foreign bodies, and rubbing to prevent inadvertent damage; use of an eye patch is recommended.
Ophthalmic procedures: Use in ophthalmic procedures (eg, corneal foreign body removal, gonioscopy, tonometry, or other short corneal or conjunctival procedures) when a topical disclosing agent is needed along with an anesthetic.
None known.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.
Methemoglobinemia Associated Agents: May enhance the adverse/toxic effect of Local Anesthetics. Specifically, the risk for methemoglobinemia may be increased. Risk C: Monitor therapy
Refer to individual monographs.
Refer to individual monographs.
Fluorescein is a diagnostic dye; proparacaine is a rapid acting anesthetic with short duration.
Onset of action: Rapid
Duration: Short
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