Time | Treatment |
Day 1 | Etoposide 100 mg/m2 by IV infusion in 200 mL of normal saline over 30 minutes Dactinomycin 0.5 mg IV push Methotrexate 100 mg/m2 IV bolus followed by Methotrexate 200 mg/m2 by IV infusion over 12 hours |
Day 2 | Etoposide 100 mg/m2 by IV infusion in 200 mL of normal saline over 30 minutes Dactinomycin 0.5 mg IV push Leucovorin* 15 mg IM or orally every 12 hours for four doses beginning 24 hours after starting methotrexate |
Day 8 | Cisplatin 60 mg/m2 IV Etoposide 100 mg/m2 by IV infusion in 200 mL of normal saline over 30 minutes |
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